Rapamycin, empagliflozin, and (insert your favorite drug for lowering LDL-C, although I think ezetimibe is superior to atorvastatin/rosuvastatin/etc) are in a class of their own. HRT for early post-menopausal women is probably in this elite tier as well, as well as GLP1RA for anyone who is overweight
In the second tier below that I’d put telmisartan and lithium, along with dutasteride for men.
The third tier would be creatine, magnesium, melatonin, taurine, as well as famotidine for those with GERD.I think you could put psychedelics in this tier for the therapeutic mental reset they offer, in addition to the longevity benefits demonstrated in mice, it’s just that the optimal frequency/dose isn’t clear yet.
I think many of these are very individual-specific though. If you can tolerate acarbose, I can definitely see having it on your list. Buproprion has been life-changing in terms of the productivity boost it’s given me, which I think is a huge factor in longevity, so it’s near the top of my personal list. Similarly, I think if something significantly reduces your stress levels or increases your life satisfaction it could deservedly be there as well.
What would be the next prescription medicine(s) you would add to this stack for longevity? Any other low hanging or potent ones out there beyond these? Exclude supplements. @desertshores@RapAdmin@Agetron
Definitely Cypionate, testosterone - TRT starting at 50 years. I started at 62 years. Matt Kaeberlein states was the best thing he did … after waiting, next to Vitamin R… rapamycin. He is 54 years in 2 days.
I wish sites like this had a commonly editable spread sheet where top NN lists can be in a single place then smeared over 100+ posts. Anyway.
I’m shocked, just amazed that HRT, all hormones replacement therapy was not in any (or I missed) top 5 lists. Both sexes; estrogen (for men, it aromateses from TRT), testosterone, progesterone (no need for men), pregnenelone (LEF loves pitching this) my health coach tips 5mg (not 50) micronized, DHEA and importantly thyroid I take NP thyroid.
=== now hitting
DIY self injected exosome sources. Got my 25B exosome delivery on dry ice yesterday. We will split it Sat. $1800 from a private org channeling a top name source. Money no object, said to be best if quarterly… A member of this group just injected 75B dose post shoulder reconstruction surgery.
Once hot but now questionable; A product called Cell Factor (googleable). The beneficial insides of exosomes but without the variablity of an exosomee source. TBD
plant based exosomes. Several companies have product for topical/skin use. TBD if ever become injectable.
=== Not yet settled protocols pre any TRIM - esk type trials, bearly concensus in private health groups;
klotho; my experience with Klotho-a and now klotho-1 is nothing noticable. BUT same with rapa and nearly the same for HRT. Maybe holding flat is a gain in and of itself. :>
VD-11; a general systemic up regulator. My order hasn’t arriived and just the coaches reviews of major up regulation, feeling better. TBD
Fox-03 yet another compound in the KLOTHO chain in/near the mitochondria
met enkephlin (??) an endogenous canabinoid good for pain
URB-597 blocks the breaking down of endogenous canabinoids. Another help for pain, anti-anxity BUT feeling better in general. TBD.
I’m close to but not in the direct flow of case studies from professional athletes/Olympic folks. In the money no object level; amazing recoveries and performance improvements. Eventually someone close to these folks will leak out the whats.
I suspect theres alot more compounds on the near horizon that are NOT out of patient targeting drug co labs, but out of small labs by genuine benefits driven private chemists.
True #1 line item on this list is sleep, next or close with clean water, clean and nutricious for you (individualized) food. An appropriate typee of exceresize.
But not far down the list are some new compounds more effective then rapa. We just need to get compound names, sources, and more DIY experiements like we have been doing here.
Has anyone here tried pioglitazone instead of metformin for metabolic/longevity purposes? Metformin mostly lowers liver sugar output, while pioglitazone works more slowly but seems to improve fat cell function and mitochondrial health. Curious what real-world experiences or trade-offs people have seen.
I can see some value in pulse dosing Maraviroc (a few months on, a few months off?) for muscle and brain benefits.
I’m also refining my fiber/fermented foods approaches (for butyrate production, etc.), trying to figure out how best to work them into my dietary habits, and what a good mix is that works for me.
My primary action area is refining my workout schedule; increasing strength and VO2Max, making things more efficient. I’ve got Blood Flow Restriction (BFR) cuffs and will start using those soon.
Effectiveness: It may take 2 weeks to see a decrease in blood sugar and up to 2–3 months for the full therapeutic effect to be felt.
Pioglitazone carries several serious warnings that require medical supervision:
Heart Failure: It may cause or worsen congestive heart failure due to fluid retention. It is contraindicated in patients with established NYHA Class III or IV heart failure.
Bladder Cancer: There is a possible link to an increased risk of bladder cancer with long-term use.
Bone Fractures: Increased risk of fractures, particularly in the hands, upper arms, or feet of women.
Liver Health: Though rare, it has been linked to acute liver injury; liver function tests are often required before starting therapy. ref
Have you tried modafinil or armodafinil before? If no, I’d consider trying those first.
So you have something to compare to if you ever do get access to the newer orexin drugs.
One of your posts on the thread you linked above (post #2 in the thread) mentions modafinil “Acts partially through the Orexin system”.
Along with some other good ideas such as bright light “Bright light (>10,000 lux) upon waking is required to synchronize the Orexin pulse”.
Caffeine “upregulates Orexin receptor expression”.
Doing those 3 together (modafinil, caffeine, while under bright light for some time) would be a powerful combo.
I took it for 1 year or so. The problem is that it makes the fat cells more insulin sensitive and I got from 14% DEXA body fat to 16%. I’ve switched to Imeglimin a few weeks ago. Too early to know if that works though. I will report back later.
