Tom Dayspring says APOB of 80 (20th percentile) is fine if you're low risk . . .

#1

but how do you assess whether you are low risk?

Low-normal BP, low-normal BMI, APOB of 76, high HDL, low Trigs, inflammation (CRP) is 1, good cardio function, resting pulse of 57 and HRV around 65, pretty much maxxed out on lifestyle behaviors–

Low risk, right?

Family history of cardio disease and stroke, homozygous for the risk allelle on 9p21 which puts me at 1.9 times risk for coronary artery disease and stroke. Additional polymorphisms that put me at risk for stroke and aneurism. The 9p21 risk manifests as an increased tendency for higher inflammation when a particle breaches the endothelium, and also a reduced ability to attenuate the inflammation and to heal. I am 74 and have a CAC score of 0.96. Lp(a) has vacillated from 30 to 40.

I am at moderately high risk, right?

Which is it, and do I intervene to get the APOB lower?

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#2

Tom Dayspring would not consider that low risk at all.

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#3

I was just registering to this discussion between Peter Attia and Ethan Weiss (a well known cardiologist and professor at UCSF medical school, and he says in this video also that there are no risks with getting your APOB / LDL-C down as low as possible. (of course the specific medicines you use to get there may have side effects for you which are another issue).

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