TMAO: A molecule produced by gut bacteria causes atherosclerosis, responsible for millions of deaths

Another factor in atherosclerosis:

Researchers have discovered that gut bacteria produce a molecule that not only induces but also causes atherosclerosis, the accumulation of fat and cholesterol in the arteries that can lead to heart attacks and strokes. This unexpected link between microbes and cardiovascular disease — the leading cause of death in humanity — is a paradigm shift. The work was published Wednesday in the journal Nature, a showcase for the world’s best science.

another microbiome paper:

Open access paper:

Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOE−/− mice

Conclusion

Tanshinone has the potential to ameliorate atherosclerosis induced by a high-fat diet by promoting the proliferation of lactobacillus, reducing the abundance of lachnospiraceae, enhancing lipid metabolism, and diminishing the production of TMAO.

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