tirzepatide
https://www.nejm.org/doi/full/10.1056/NEJMoa2107519
GIP agonism might be better for the bones too (compared to Miglitol - a better acarbose? Increases UCP1, decreases gastric inhibitory peptide (GIP) + decreases body weight )
Can also increase osteoblast activity - Tirzepatide's Unique Mechanism of Action - GIP/GLP-1 Dual Agonist - YouTube
It IS possible to get via india-mart
THEN THERE IS a BETTER one (LY3437943) -
Coskun et al. demonstrate that LY3437943, a triple glucagon, GIP, and GLP-1 receptor
agonist for the treatment of obesity and type 2 diabetes, can reduce body weight through
increased energy expenditure and reduced calorie intake in obese mice....
God I find out about things so late… I only learn of semaglutide within 1 year of learning of ALL the newer stuff (similarly with canagliflozin)
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Friend I know just tried it and says it’s way better than semaglutide
Better in what ways? Please provide more detail…
20% weight loss versus 15%
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Can 1mg tirzepatide work as well as 1mg semaglutide? (tirzepatide uses higher doses but is more effective, so uh, maybe half or 1/4 the dose of tirzepatide for similar effect?)
Tirzepatide is also way more expensive per mg.