Timing of Taking Rapamycin, Metformin and Colchicine vs Urine Frequence

I have followed David Sinclair’s recommendation to take metformin (500mg) at night, to further “autophagy” and added rapamycin (1mg) for the same reason. Plus Colchicine and Statin for added cardioprotective effects.
I have noticed that I have increased urine frequency if I do so at night as otherwise I do not need to get up at night at all.
I theorized that both metformin and colchicine may have contributed to “the new pattern” (get up at night to …). Mechanisticallyit seems to be the plausible explanation as my kidney function otherwise has not changed.
Does anyone want to add their speculation here? Thank you.

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