I watched that video interview on the substack.
“During our interview, Dr. Fahy made a striking claim: Most people who die after age 60 actually die from immune system failure. Not directly—but because their weakened immune systems can’t fight off cancers, infections, and other threats that younger immune systems would handle easily.”
Not sure why Dr. Fahy did not mention the most common cause of death - cardiovascular disease.
What makes you think lipid lowering meds or any others would cancel out TRIIM effects?
Stop stressing over gray hair. It just means your body is actively clearing out damaged pigment stem cells that carry a cancer risk.
https://www.nature.com/articles/s41556-025-01769-9
McSC fate tracking in mice revealed that McSCs undergo cellular senescence-coupled differentiation (seno-differentiation) in response to DNA double-strand breaks, resulting in their selective depletion and hair greying, and effectively protecting against melanoma.
Was reading about this mouse that lives 5x longer than other mouse strains. They find these mice have fully functional immune systems and their thymus is not involuted up to death. They speculate this is one of the key elements that allows them to live 5x longer.
One more hint that restoring the human thymus might be the right choice.
Actually, I was asking people with better knowledge if that could be the case, but personally have no idea as I’m not very well versed when it comes to meds. So, from your question I assume you think it is fine to continue with my normal daily meds (mainly lipid and glucose lowering) while also doing TRIIMX
Ok I see. I can’t really think of any contraindication personally. I would think probably more beneficial together. I use them all together myself
Glucose lowering drugs are very much a part of TRIIM, so you need them. Statins have little to no effect on IGF1, if that’s what you’re worried about. It probably doesn’t make to take high/frequent doses of rapamycin while doing TRIIM since one revs up IGF1, while the other one dampens it.
I didn’t say I was stressing over gray hair. It doesn’t bother me in the least. In my circle of friends I can’t think of anyone who stresses over their gray hair. On the other hand, I do know of a lady or two who dye their hair. I suppose they could be a bit stressed.
What would the rapamycin dosing plan be. Just pause? Or you do every 4-8 weeks?
I honestly don’t know about this… see this picture of Greg I took when I was talking with him in Berkely last month. I couldn’t tell if its dyed or not… You can double click on the image to make it large.
He looks great for his age. But he mentioned he doesn’t exercise much, I think he said he recently added a chin up bar in his office to do a little more exercise.
I’ve personally paused rapamycin for this, partially because I don’t dose rapamycin all year long, and partially because I don’t want it to interfere with the protocol. But I can see low dose rapamycin working if one wanted to, as long as there is enough igf1 stimulation.
Good tells are beard, eyebrows and body hair. They all grey at different rates (scalp usually first) but many people who color their hair will focus more on their scalp than anywhere else.
interesting. Actually, when looking at this angle his hair does look pretty natural. In some of the clips the lighting makes a big difference, so it’s hard to tell
Found this interesting due to my light eye coloring and red hair tint… which is really pronounced on my current arm hair. Neanderthal traits… maybe I am in the .5 -2% percentile of Neanderthal genetics. Might explain my easier muscle growth and retention using HGH.
Neanderthal growth hormone receptor increases muscle mass in people today – Popular Archeology
https://science.org/content/article/neanderthal-growth-gene-turns-modern-humans-muscle-heads
This definitely looks like natural hair to me… it doesn’t appear dyed a all.
i have definitely reversed a lot of grey hair. In my fifties my chest hair was very grey and now it is brown which i attribute to 7 years of rapamycin. At 73.5 only the beard hair on my chin is grey - none on my head
