The Ozempic Craze Could Put These Companies on a Crash Diet

Treatments for longevity would also affect the various businesses that produce drugs & devices to help people with the problems of aging.

People on drugs like Wegovy are less likely to crave Krispy Kremes. And if they stay on the drug for years (unlikely at this stage due to restrictions on most insurance plans), their weight loss could help prevent all sorts of complications, like Type 2 diabetes. That could in turn mean fewer sales of things like insulin pumps and sleep apnea machines. And people who slim down could hit the cancel button on their dieting apps.

also:

All this is very hypothetical for now: Paying for the treatment of 100 million obese Americans would literally make Medicare insolvent at the drugs’ current prices. Eventually, though, as data shows longer-term benefits that extend beyond weight loss, insurance coverage will expand.

These GLP drugs appear to work well at a significant price, and until we can overhaul the typical horrible American diet, it’s the best we have. My concern is that even with a 15 kg weight loss from Ozempic, that still leaves many people obese and unhealthy.

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I suspect people on Wegovy are going to keep eating donuts because the drug cancels out the negative effects of eating donuts. Or at least, the obvious negative effect, getting fat. I don’t know if those drugs keep you in good metabolic health - will you be a skinny diabetic if you eat poorly on Wegovy?

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People on GLP1 receptor agonists report reduced ā€œfood noiseā€ in their heads and cravings. I don’t know that it’s been studied, but I would expect that even without the dietary counseling they get in the trials, people on these drugs will eat more healthily. At minimum, they will eat less garbage as a function of eating less food.

You say 15 kg of weight loss is common on Ozempic (low-dose semaglutide), but people on high-dose sema (Wegovy) lose 15 percent of their weight, and newer drugs in the class are even better. On retatrutide (a triple-hormone receptor agonist for GLP-1, GIP, and glucagon), people lost 24 percent of their body weight at week 48, with the trends pointing to more pounds to be shed:

https://gwern.net/doc/longevity/semaglutide/2023-jastreboff-supplement.pdf

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Lmao

image
From Nassim Taleb Twitter.

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Can’t say that im upset about junk food companies losing money.

Does anybody know if insurance companies are limiting duration of coverage for these drugs?

FWIW, I find this:

some insurance companies and employers are halting coverage of these medications due to increasing cost

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My story with Ozempic is worse than others. I’m a professor in Texas with an MD from Mexico, and I’ve had type 2 diabetes for more than 20 years. I used metformin for the last two decades and I experienced some gastrointestinal side effects.

The main reason why I started injecting Ozempic in April 2023 was because it was only a once-a-week injection, and I was tired of taking a lot of medications twice a day for so long.

The burning pain in the back never disappeared. But in August, a worse burning pain in my genital area and buttocks appeared.

I noticed ā€œpiecesā€ of skin on my toilet seat and on the tissue paper when I cleaned the area. I checked, and my genitals, anus, and buttocks were severely burned, some areas with charred skin. It was as if I was exposed to sunlight for days.

HAPPY THANKSGIVING EVERYONE!

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As far as Medicare goes, I do not know if it covers this medicine at this time. Does anyone have proof that Medicare covers it right now and for which patients?

Let’s assume Medicare does cover the treatment and 100 million on Medicare want it. Can the US Govt buy the company or buy the treatment for a reduced value?

I do not work in medicine or pharma at this time.

Anecdotes are completely worthless and anyone who thinks obesity is preferable to medication doesn’t have their priorities straight. Having too much fat mass is not merely a cosmetic condition, it’s as hazardous to your health as smoking or being alcoholic. Do I have to post pictures of morbidly obese people literally rotting to death? Even if ozempic literally killed 1% of all patients, it would still result in a larger reduction in all cause mortality than not using it because obesity is just that bad.

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Please don’t, thanks :slight_smile:

MHO, what would be better is to figure out what is causing obesity, so then people could stop doing it (at least, some of them).

FWIW, I ran across a very long post recently suggesting one cause may be n6 oils (the ā€˜heart healthy’ stuff we are advised to eat instead of butter). Does Linoleic Acid Induce Obesity? Part 1

I’m not saying it’s true, but I still avoid vegetable oils & the things made from them (like salad dressing) like the plague. I’m sure that if I ate like my relatives I would be the size they are. For me, it’s not genetics but eating style.

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