The mTOR rebound effect has been kind to my skin?

@Phillipe just seeing this.

That is because that is the link for the US website of BOJ where they released new spfs that are compliant with FDA approved ingredients.

From Stylevana, you can get the non US version… aka, the good stuff…

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The stuff finally came. It’s awesome! It does go on like a smooth glowy moisturizer. The only thing I don’t get is how much to use. I put in quite a bit and made my face a bit too shiny / dewy when I prefer a matte finish but I wonder if that just means I overapplied. Also seemed to tone down with time, the “dewiness,” that is.

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YAY! Next time you order, if you didn’t, try the other/newer version called Aqua… that is a little less moisturizing, so perhaps it will give you the finish you are going for?

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Will try next! I’ve got enough to last me a long time for now and I’m definitely not complaining

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Offered from Stylevana a month ago, haven’t received it yet and according to a tracking they sent they are still packing it… won’t use them ever again.

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@LaraPo The checkout process was pretty glitchy and I don’t think I ever received a tracking number. But in about 2-3 weeks I got the goods and the sunscreen IS amazing. I think the best way to go is finding someone local to ship you some in bulk. But it’s the only sunscreen I’ve tried so far that I can easily commit to and wear daily. Without that the whole tretinoin path probably does more harm than good.

Speaking of… I did order and receive the facial tape but haven’t used it yet because I can’t figure out how to make my routine work. It says to use it on completely dry skin with no product on it to ensure good adhesion. But nighttime is when I layer on my tretinoin and moisturizer. Any tips?

p.s. also ordered Cytocare and waiting for it to arrive. Will try the mesogun for injection but with a view to graduating to meso needles once I’m a bit more comfortable with the process.

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I’ve only had quick turnaround with them, but yeah, as @medaura said, it does take a while for many people… I’ve only heard delayed vs not showing up. Until recently, iHerb sold it but now they only have the made for the US version which is a bummer.

If it doesn’t come soon, don’t forget you can have your credit card charge it back. You have 60 days for that.

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Re the tape. Skin doesn’t have to be completely dry. I don’t use moisturizer at night, no do I use any facial cream at night before I apply tape. Instead I apply serum, wait 10 min, then apply tape.

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I don’t HAVE to use moisturizer but I do have to use tretinoin because it’s working wonders and I’ll never go without. I’m still at the stage where I need to buffer it a bit with moisturizer though otherwise I’ll peel like a snake so one has to go with the other — for now. I’ll maybe look into applying tret + moisturizer earlier in the PM and then washing my face off right before bed, before taping, if the timing works.

I somehow don’t have a good feeling about using tretinoin before taping. I think it’ll increase peeling. Just my guess. I don’t use tretinoin so I don’t know for sure.

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Ok my haul finally made it from China. Let the fun begin!

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Well… that didn’t turn out to be much fun, I regret to own up. One of the products I got is Hyaron:

Hyaron 10x2.5ml - FYAB.

I had bought it as something to play around with to perfect my injection technique / procedure before moving on to the really good stuff since it had the lowest retail value of all the other mesotherapy products. After much research I injected it with the ez meso gun and when I noticed the little bumps under my skin, I figured that’s great as it means the product has made it where it needs to be and will get absorbed soon. Well… that’s not how it panned out. This was a LIGHTLY cross linked HA product, meaning it had a bit of slip / viscosity. And yes it’s meant to be injected superficially as mesotherapy but if you read the fine print — not literally, by that I mean if you research some MORE on YT beyond the first obvious results — it turns out that it can also act as a light, fluid filler when injected deep in the skin. And this became a problem as the meso gun injects directly into the skin at a straight angle, not at roughly 15 degrees as one would with a single needle, and as I was too chicken to try though I should have. So the bumps persisted and I’ve only slowly been able to smooth them out after throwing my kitchen sink of devices at my face: TECAR, local dynamic micromassage, radiofrequency, even friggin’ shockwave therapy! Yes, shockwave, on my CHEEKS! Otherwise those bumps would have settled there for months —
I shudder at the thought.

It took days to get them to smoothe out and even now I have a tiny bit of surface irregularity where I made the injections. I have something in the neighborhood of post inflammatory hyperpigmentation going at the injection points too, because there was trauma from squeezing a thickish, viscous substance around 1-2mm deep. Thankfully I have skin that doesn’t hyperpigment from trauma and the dark / bruised spots are fading every day and should be completely gone in about a week or two max but… I went into this with almost glass skin. Now it’s … I don’t know what to call it, decent quality parchment paper? :joy:

Be careful what you do at home, boys and girls.

This makes me skittish to try out the other products or even to try hyaron one more time and inject it as God intended, i.e., with a mini needle right under the skin. I’m waiting for my dermaelectroporation device to arrive this Thursday and will “inject” a skin healing cocktail I ordered with my stash and that should hopefully help speed up the fading process but it will take me some time to get brave enough to do needles again, even though I fully understand where I went wrong and how to fix it.

This seems pretty cool by the way and I’m excited for it as a lot of the supplements I take in rotation have solid data behind them as skin injectables so I can take them out of the pill, dissolve them in water (well this only works for the water soluble compounds) and apply the solution topically. The machine makes sure most of it makes it past the skin barrier.

https://aexelbiomed.com/dep/

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Thnx for the update… I used to follow a FB group of self-injectors, and yeah - definitely observed a learning curve with most of the members… which made me sober up and realize I am not the right person to tinker with any of that… but many are;)

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It’s one of those things… even when you think you know, you don’t know, and you don’t find out you don’t know until you try. In my case I thought I was being extra conservative by using the EZ Gun because it controls the act of injection itself and there’s no guesswork or technique involved in how to enter at any particular angle. But I’d have been better off doing the superficial injection myself with a tiny needle at a tiny angle than outsourcing the act to the machine at a straight angle. It depends on the product of course and I didn’t know the nature of the one I was using nearly as well as I thought I did (its being cross linked, lightly or otherwise, was news to me and not really mentioned in the product description).

But it makes me wonder if I’m making similar mistakes with what I ingest :confounded:. There I won’t know the damage I might be causing until something major gives me a reality check.

For now I’ll strictly stick to the dermoelectroporation device in lieu of actual injections. It’s expected to get here tomorrow.

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I have a lot to say about this device. My preliminary report is that it’s magic. It does substitute injection, really and truly, so long as the compound is water soluble. Again I tried it with the lightly cross linked hyaluronic acid meant for mesotherapy. I rubbed and rubbed until it disappeared from my face and part of me initially thought the solution must have evaporated. But no, I now see it under my skin, in the shape of my cheeks. It’s not particularly attractive, almost chipmunk like when I smile, because I rubbed it in mostly toward the front of the cheeks whereas I should have done the sides and top, around the highest point of the cheek bones. I didn’t honestly expect it to work this well! So of course now I need to get busy at work to speed up the breakdown of this very light filler. Definitely don’t want it stuck in my face so I’m throwing the kitchen sink at my cheeks again and I imagine it will dissolve in a few days like it happened to the papules last time around. But this is a miracle of a technology. Without injection you can carry water soluble cocktails to the other side. As soon as I’m done dissolving this I’ll start with the skin boosters I bought. I also have Radiesse I plan on using in hyper dilute form but that will be my capstone project after I’m done perfecting technique. Clearly it matters very much where you “inject” i.e., where you rub it in and there’s no undoing Radiesse so I’m being conservative.

For more info:

They’re selling it for $14,000! It’s the exact same model, from Mattioli in Italy, but of course made in China. I paid $171 + $39 shipping + $35 optional consumables.

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You are a fountainhead of information in this area… I have never heard of this before (perhaps like most guys here), very interesting. … Medaura, can you share a link to the device that you purchased?

Dermoelectroporation (DEP), also known as needless serum infusion, is a non-invasive skin rejuvenation technique that uses controlled electrical pulses to enhance the absorption of active skincare ingredients deep into the skin. This technology allows for the delivery of both micro- and macro-molecules without the need for needles or injections.

How it works:

  • Controlled Electrical Pulses:

DEP uses gentle electrical pulses to temporarily open micro-channels in the skin’s cell membranes.

  • Enhanced Absorption:

These temporary channels allow for the efficient penetration of active ingredients, such as serums, into deeper layers of the skin.

  • Non-Invasive and Painless:

The procedure is non-invasive and pain-free, offering a comfortable experience for patients.

  • Deep Penetration:

DEP can deliver ingredients 3 to 5 mm deep into the dermis, reaching the subcutaneous layer.

  • Versatile Applications:

DEP can be used for various skin concerns, including fine lines, wrinkles, dullness, and even for hair restoration.

  • FDA-Cleared:

DEP technology is FDA-cleared and considered a safe and effective alternative to traditional injections.

Benefits of DEP:

  • Enhanced Product Efficacy:

By delivering ingredients deeper into the skin, DEP maximizes the effectiveness of skincare products.

  • No Downtime:

Unlike invasive procedures, DEP requires no downtime, allowing patients to resume their normal activities immediately.

  • Safe for All Skin Types:

DEP is suitable for all skin types, including sensitive skin, and is generally considered safe.

  • Immediate and Long-Term Results:

Patients may notice immediate improvements in skin hydration, texture, and radiance, with long-term benefits from continued treatment.

  • Cost-Effective:

Compared to surgical alternatives, DEP offers a cost-effective way to rejuvenate and improve skin appearance.

  • Hair and Scalp Restoration:

DEP can also be used for hair restoration by delivering nutrients and growth factors to the scalp.

In summary, dermoelectroporation is a non-invasive and effective technology that uses controlled electrical pulses to enhance the absorption of skincare ingredients, leading to improved skin appearance, rejuvenation, and even hair restoration.

Related:

and I know that @LaraPo has mentioned Profhilo. This Dr. doesn’t think DEP will work that well with this technique:

Does needleless transdermal electroporation of Profhilo work?

There are no published studies on needleless Profhilo available (I could not locate any; and if you do find any, please share them with me).

Based on what we know about Profhilo and how transdermal electroporation works, I am doubtful about its effectiveness. Transdermal electroporation improves the uptake of skincare in the epidermis; not the dermis which is the correct layer for Profhilo injections. Most of the studies that looked at drug delivery using transdermal electroporation demonstrated increased uptake in the epidermis; not the dermis.

These hyaluronic acid complexes in Profhilo will not be able to enter the dermis as there is a basement membrane that separates the epidermis and dermis. Based on this, patients who undergo needleless Profhilo may experience some skin hydrating benefits in the epidermis. The collagen and elastin building benefits which arise in the dermis of the skin are unlikely to occur with needleless transdermal electroporation of Profhilo.

https://www.drrachelho.com/blog/needleless-profhilo-plasma-shower/

https://www.theaestheticguide.com/aesthetic-dermatology/fda-cleared-transderm-dep-delivers-compounds-without-injection

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@LaraPo later said she didn’t care much for Profhilio compared to Cytocare so I only purchased the latter. I think that doctor is full of shit as DEP allows compounds to penetrate 3-5mm deep which is indeed way past the epidermis. My main long term interest, beyond the skin boosters I’ve bought and many new ones I can concoct (think, niacinamide + ascorbic acid + carnosine or whatever dissolved in reverse osmosis filtered water — your imagination is the limit), is getting Radiesse under the skin. That’s a proper biostimulator that induces the production of new collagen AND elastin. Radiesse of course being the brand name, the active ingredient being hydroxyapatite. Providers are already doing it with success! I could use sculptra that way too but it only produces collagen, not elastin.

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I forgot to mention the vendor:

https://x.alibaba.com/AzpxFd?ck=minisite

Ask to speak to David Ma. If you order from them please let me know. I don’t have any financial incentive obviously but if I am able to tell a vendor that I’ve referred sales to them they’re typically much more attentive to anything I might need in the future.

This one is the vendor of the skin boosters and injectables. They’re not even listed as products on their site but the rep gave me a private catalog and the prices are amazing. They were original products when I got them, at prices I’m still pinching myself over. Ask to speak to Annis Dang:

https://x.alibaba.com/AzpxKj?ck=minisite

Again, if you end up ordering, please let me know. They’re always a bit disappointed that I only want tiny quantities which are barely worth their time so I like to be able to tell them so and so was my referral. I get better treatment going forward.

As to the product itself, I am including this one below because it’s an OK product description but it’s obviously still overpriced so don’t buy it. Just look at it to do your initial diligence then talk to David Ma from my first link:

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Also I think it quite possible that physician is confusing dermoelectrlporation with plain old electrophoresis. They sound similar but the parameters of the former make it work like magic whereas the latter just gives minimal penetration and can damage both the skin and potentially the molecules being penetrated as it affects their polarity.

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Yes, I wasn’t impressed with Profhillo. It has to be injected using the method called BAP (bio aesthetic points) in 5 points only. It supposed to distribute itself evenly on face after that. I didn’t see it happen in my case. It could be an injection error (injected too deep) or a benefit that couldn’t be seen. I like to see the result either immediately or the next day. With Cytocare, there’s a result that could be seen in 2-3 hours.

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