The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier

[RapAdmin]

Taken together, our study introduces a unique and efficient model for large-scale antiaging drug screening in vertebrates and suggests sapanisertib as a potential therapeutic option for treating premature aging and promoting healthy aging.

Paywalled paper:

Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug

https://www.pnas.org/doi/10.1073/pnas.2413719122

Sapanisertib

Source: https://x.com/davidasinclair/status/1895939773455614448

https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-300/subpart-B/section-300.50

[RapAdmin]

But - then here is some new input from Dudley Lamming, who is much more an MTOR expert (having worked in David Sabatini’s lab as a PostDoc) than David Sinclair:

Source: https://x.com/LammingLab/status/1895968197867885006