The most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome (Patrick Collison)

@cl-user , perhaps our next area for exploration…

I’m lucky enough to have a great doctor and access to excellent Bay Area medical care. I’ve taken lots of standard screening tests over the years and have tried lots of “health tech” devices and tools.

With all this said, by far the most useful preventative medical advice that I’ve ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments.

Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know.

I don’t know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars.

(One often sees papers and articles claiming that models aren’t very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents’ reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.)

There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

Source: https://x.com/patrickc/status/2045164908912968060?s=20

Related:

I Gave Claude Code My Whole Genome (And It’s Amazing)

Of course, the counter argument is…

Source: https://x.com/AlexTISYoung/status/2045179927478325716?s=20

Seems likely he knows what he’s talking about:

Just as soon as the consumer genomics industry is willing and able to provide us regular human beings with validated commercial reports at a reasonable price, I’m sure we’ll stop using AI instead.

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I’m not saying it’s not worth it. Maybe it is. I’m saying, this is a whole lot more expensive than a year’s worth of Claude-pro and that doesn’t include the interactive AI, which is an add-on. (About $100/year). Maybe it’s worth it, but it’s not cheap.

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What are the best ways to get our whole genome sequence?

See this thread on X:

here: https://x.com/patrickc/status/2045252809713737825

I’ve paid $400 to sequencing.com for my full genome sequencing, which I expect will take a few months to complete before I can access my data file. While waiting, I’m teaching myself genomic analysis basics with Claude’s help to avoid paying subscription fees for report generation. I think that that with some effort, I can ensure my reports use the highest quality and most recent population studies (GWAS datasets). My limited background in R coding, combined with Claude’s assistance, I hope will give me the skills needed to update my reports as new population studies become available. My plan is to first obtain my percentile rankings and then use AI to focus on lifestyle interventions that address my highest risk areas.

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