The most exciting REAL anti-aging drugs (Andrew Steele)

Andrew is finally starting to come around to rapamycin. In his book he was not very up to date on the research on rapamycin, but since then he seems to have read much more. Again, nothing really new for most people here, but Andrew is addressing a broader segment of the population and introducing them to these types of longevity drugs.

If you just want the lowdown on a specific drug…check out the video chapters!
00:46 Rapamycin
02:34 Senolytics
04:49 Metformin
06:18 Taurine
07:24 Statins


AFAICS most senolytics are HDACi s and hence likely to be senomorphic in effect.

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Interesting! Thanks for sharing @RapAdmin

As a side note, I listened to this episode the other day and he mentioned Rapa a few times in it as well:


@RapAdmin I never read his book. Anything that is not covered here regularly?

No, I would consider it a “longevity lite” type of book. Not aggressive enough for my tastes. He has a PHD in physics so from my perspective, not the ideal kind of background for a person evaluating longevity drugs and therapeutics.

Interesting coverage and introduction to different areas of research in the biology of aging, but when it came to actionable information, here is what he focused on…

More on Andrew Steele (background):


Sounds like something a mother would tell her teenage daughter. :sweat_smile:


Thanks! you are like an encyclopedia!

My degree is in Physics (also from the University of Oxford). Hence I would disagree that a background in physics is of no assistance.

However, Andrew Steele tends to take the orthodox medical establishment position again treating uncertainties as a big hazard to be avoided rather than an area with unknown opportunities.


Funny. I was thinking it was the sort of advice you’d give a 30 year old. But, once you get past the mid point, more aggressive interventions are sensible.

Still, the big levers are the same:
(1) get good sleep / manage stress (these go together for me)
(2) don’t eat too much / get rid of the excess body fat (I used to think <20%, but Lustgarten is<10%)
(3) don’t eat too often / let the body burn fat
(4) eat your veggies/ fiber (maybe there are exceptions but…)
(5) exercise the body and brain (sports > exercises)
(6) avoid toxins (cigs, fire smoke, mold, pesticides, etc)
(7) get outside AND avoid almost all UV
(8) do your happy thing

I am a work in progress, still. And I worry most about letting the small things, like supplements, become a crutch that lowers my motivation to work on the big levers that would really make a difference.

Go ahead, hit me with it….

  1. be short.
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That won’t be easy (6’2”).

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