This seems to confirm some of the most common pathways we know about: MTOR, AMPK, IGF/GH, TERT, FGF, but some new ones to pay attention to also…
Candidate molecular targets uncovered in mouse lifespan extension studies
Expert opinion
To increase the translational potential of mice life-extension studies to clinical research several factors are crucial: standardization of mice lifespan research approaches, the development of clear criteria for control and experimental groups, the establishment of criteria for potential geroprotectors, and focusing on targets and their clinical application. Pinpointing the targets affected by geroprotectors helps in understanding species-specific differences and identifying potential side effects, ensuring the safety and effectiveness of clinical trials. Additionally, target review facilitates the optimization of treatment protocols and the evaluation of the clinical feasibility of translating research findings into practical therapies for humans.
Paywalled Paper:
https://www.tandfonline.com/doi/full/10.1080/14728222.2024.2346597