This protocol is an theoretical biohack that can potentially address aortopathies such as aortic dilation. I make no medical claim and have no conflict of interests, as I have nothing to gain here other than sharing this protocol for critical review. I have only added brand names to specify details and have no affiliations with the vendors.
I’ve named this the Iaso Aegis Protocol with respect to the goddess of recovery and recuperation (Iaso) and the ancestral Greek shield (Aegis).
What I would like is that the information I am sharing is reviewed and discussed.
I plan to use this protocol for myself where n=1. If you have any question or concern, please be respectful and I will willingly answer what I can.
This work is the result of several months of study and nth reiterative passes thru several AI engines, namely Gemini, ChatGPT, and Claude. This idea came from our great RapAdmin in this rapamycin forum 
I. DAILY ITEMIZATION & DOSAGES
Morning (10:00 AM)
Peptides:
SS-31: 5mg SubQ (Daily, Mon–Fri) for 4 weeks OR MOTS-c: 5mg SubQ (Friday only) for 4 weeks
GHK-Cu / KPV: 2mg / 500mcg SubQ (Mon–Fri)
Retatrutide: 1.5mg SubQ (Mon/Thu) (*Tirzepatide preferred)
Daily Supplements:
Dill-Berry Extract: 10% Prep
Vitamin C: 500mg
Magnesium Bisglycinate: 200mg
5/2 Staggered Supplements (Mon–Fri):
PlantVital Resveratrol: 600mg
Nutrawave Quercetin: 600mg
PlantVital Berberine: 500mg
Meriva Curcumin: 500mg
EBYSU Green Tea Extract: 500mg
Bamboo Silica: 300mg
Natural Factors B Complex: 1 Cap
Midday (2:00 PM)
Daily Supplements:
Herba Complex (Zinc/Copper/Sel): 1 Cap
Nutratology D3+K2: 2 Caps (2,000 IU D3 + 240mcg K2 total)
Generic D3: 3,000 IU
Vitamin C: 500mg
5/2 Staggered Supplements (Mon–Fri):
California Gold Nutrition NMNH Complex: 1 Cap (NMNH 250mg, CoQ10 100mg, PQQ 20mg, L-Ergothioneine 5mg)
L-Citrulline: 2g (BP Responsive)
Evening (10:00 PM)
Daily Supplements:
Losartan: 25mg
NAC: 600mg
Manganese Glycinate: 5mg
L-Proline: 2g
L-Lysine: 3g
Glycine: 5g
Vitamin C: 500mg
Magnesium Bisglycinate: 200mg
II. THE SAFETY BREAKERS
HR Ceiling: If Resting Heart Rate > 75 bpm for 3 days → Reduce Retatrutide dose.
BP Floor: If Systolic BP < 100 → Stop Citrulline immediately.
III. SUGGESTED BLOODWORK MARKERS (3–6 MONTHS)
IGF-1: Target 150–200 ng/mL; monitors safe growth signaling window.
hs-CRP: Target < 1.0 mg/L; tracks systemic inflammatory load.
Homocysteine: Target < 9.0 μmol/L; essential for vascular wall integrity.
25-OH Vitamin D: Target 50–70 ng/mL; optimized for vascular smooth muscle function.
HbA1c: Target < 5.4%; monitors glycation risk and metabolic efficiency.
Lipid Panel: Target LDL < 100 / HDL > 50.
FINAL PROTOCOL NOTES
Phase 1 Review Flag: [REVISIT AFTER 4 WEEKS OF SS-31]. Assess RHR and recovery before switching to MOTS-c.
Ingestion Timing: Based on waking cycle (~9:00 - 10:00 AM); adjust accordingly.
Tirzepatide Preference: *Tirzepatide preferred over Retatrutide due to specific protective evidence in aortic models and lower heart rate impact.
Tesamorelin Utility: Included for lean mass retention; can be excluded if muscle wasting is not a concern. [Currently Shelved].
Dill-Berry Synergy: Provides biological signaling for elastin assembly, utilizing Mid-Day Copper and Evening Aminos for reconstruction. Must use European Dill, not East Indian Dill. 10g dill seed is blended with ½ cup berries and 500mL water; soak in fridge for 1-2 days before filtering.
So yea, thanks to those who read and reviewed. I hope this protocol can lead us into a new future for treatment of these devastating diseases.