FWIW 20 mg of telimisartan is the smallest dose. Goes up to 40 and 80. A wide range to experiment with.
Not knowing of a possible benefit of taking PM, or even another 20mg in PM, I’m taking upon waking and my numbers drop 5pts off both high and low numbers. Just 5 pts at 20mg. 129/86 to 124/82 with fluctuations. One might ask is a drug worth such a small gain? AND is lowering where I’m at does it have any anti aging benefit? Its my resting heart rate, RHR that I’m frustrated with at 72yo good shape. It running high 70’s. 20mg telimisartan did drop that 5-10 beets.
I took 200mg modifinil this am and RHR is 84 with 20mg telimisartan. I’m not surprised that handfulls of pills that some or some combo is raising my RHR. I don’t have a ring to measure HRV.
I buy my telimisartan etc from alldaychemist.com. So I can play with dosing all I want, just buy more.
Another reason why I’m experimenting with telimisartan is that it also helps glucose control and when I read up it also had a bigger health foot print like the recent posts here on SGLT2’s having off target benefits.
I was just having a conversation with Opus about it.
I took it for a few days a few months ago, but then stopped. I just restarted 5 days ago after getting an rx for 20mg pills.
Opus wanted me to start at 10mg because I don’t have high bp. I asked him what benefits I could expect at 10mg vs 20mg and he said:
What you’d hope 10mg buys you long-term:
Blunt angiotensin II — less of the signal that drives vessel stiffening and injury
Cardiorenal protection — easier load on heart and kidneys over time
Kidney/protein protection — less albumin leak, slower kidney aging
Arterial stiffness — softer, more elastic vessels
Matches your ACE D/D — you make more angiotensin II than average, so blocking it fits your genetics
Same benefits at 10mg vs 20mg — just potentially weaker at 10mg, since these are dose-graded. You trade some effect for less BP drop.
Two you keep fully at 10mg (not dose-dependent):
24-hour coverage — the long half-life holds
Brain penetration — property of the drug, not the dose
PS, apparently there is no PPAR-y benefit we can expect to have at low doses. “He” seems to feel it would even very ify at 40mg. (I, of course, have no idea!).
A $399 Smart Ring Aims to Replace the 150-Year-Old Blood Pressure Cuff
A three-year-old startup says it has produced a smart ring that can track blood pressure as accurately as a traditional arm cuff and that — eventually — it could be able to make medical diagnoses. If the company, called Vital Signals, can successfully deliver on the promise, it would represent a significant breakthrough in consumer wearables.
The $399 Signal Ring is unique in that it doesn’t require a traditional blood pressure cuff for users to get started or periodically calibrate the data. And, unlike wearables from certain high-profile companies such as Apple Inc., it provides not just blood pressure trends, but actual readings.
Hilo.com now selling the Hilo Core continuous wear, band and BP cuff in the United States. $238.98 — Cuff and band $$89.99 + $149.99 for 1 year subscription.
“Next-generation blood pressure monitoring. The only clinically certified cuffless and continuous solution. Designed to support meaningful reductions in blood.”
I have a Katalyst that I sometimes bring when traveling
It seems to work.
But be aware to not overdo it, it there are potential risks of rhabdomyolysis (often shortened to “rhabdo”). When overworked muscle fibers break down and release their contents (particularly a protein called myoglobin) into the bloodstream, which can overwhelm and damage the kidneys in severe cases.
Eduardo Otaola, developer of Cora Merrick Park in Coral Gables, Florida, says the high-end Miami-area condo project designed by Arquitectonica will boast longevity-focused features, including air purification systems and electrification, and cost roughly 10% more to complete. But when the building opens in 2028, he expects a 25% to 30% premium in sale prices versus a comparable unit without the health focus.
Isn’t it inaccurate at night compared to other ABPM’s?
The subscription added on is a minus, they could at least remove it for older devices (and not only accounts). Rent seeking:
The classic example of rent-seeking, according to Robert Shiller, is that of a property owner who installs a chain across a river that flows through the owner’s land and then hires a collector to charge passing boats a fee to lower the chain. There is nothing productive about the chain or the collector, nor do passing boats get anything in return. The owner has made no improvements to the river and is not adding value in any way, directly or indirectly, except for themselves. All they are doing is finding a way to obtain money from something that used to be free. Rent-seeking - Wikipedia
I’ve had the Hilo for two weeks now. Here are both my Monthly Trend Graph, with 527 measurements so far and a data export. Hilo_Blood_Pressure_Report_Aug2026.pdf (32.2 KB)
My BP is surprisingly consistent day and night. I don’t know how accurate the band’s readings are, but the longitudinal data series is of some use to me. The device is calibrated against an upper arm blood cuff that Hilo supplied
Put one of these in your car with a comma 4, use DIY full-self driving car, in the future reduce risks on the road. chestnut doesn’t have a new driving model yet, a 1B parameter driving model soon, & they will be able to fit a 8B (4 gb) model. The comma 4 is plug in self-driving to cars.
A nearly $95 million Seattle research effort aims to use artificial intelligence to design biological molecules that don’t exist in nature.
Why it matters: The AI BioDesign project, which was announced Thursday and will run at least five years, is looking to combine AI and bioscience, with potential applications from cancer treatments to enzymes that break down plastics.
Driving the news: The project is supported by the Fund for Science and Technology, a nonprofit foundation launched by late Microsoft co-founder Paul Allen’s estate.
The Allen Institute will receive $46.1 million, the University of Washington will receive $43.8 million and the Fred Hutch Cancer Center will get $4.7 million, according to the Allen Institute.
How it works: AI models will propose new biological designs, which scientists will build and test in the lab. The results will then be fed back into the models, helping them make better designs in the next round.
The idea is to explore possibilities that evolution hasn’t produced and, in the process, learn more about the fundamental rules governing how biology works.
What they’re saying: Evolution creates diversity, but “it is a slow process,” said UW researcher David Baker, who won the 2024 Nobel Prize in Chemistry for pioneering the computational creation of new proteins.
Zoom in: Among the first targets are custom proteins designed to latch onto disease, genetic switches that can turn genes on or off, and tools that can selectively destroy or stabilize proteins, according to Jay Shendure, lead scientific director of the project.
The bottom line: Researchers hope the project can harness AI’s potential for good — turning biological possibilities into medicines, materials and technologies that work in the real world.
