The DMT+Cybin thread (is it the tryptamine with highest upside to downside risk?) Will Bryan Johnson try it? Can it be pro-longevity too?

It is the central component of ayahuasca, so it is legal in many South American countries + Colorado (where DMT dosing centers will open up next year, and reduce A LOT of the friction b/c you often need an icy bong to vaporize it safely). AND you can try it half-legally in Portugal.

In Colorado - starting June 1, 2026, the Natural Medicine Advisory Board can allow DMT, ibogaine, and mescaline in licensed healing centers

It is also shorter than other psychedelics, making the downside risk way lower than most of them (and safer for time-compressed people to take them slightly more frequently). Some people really heal from it (I know bc I once cohosted a DMT party and it cured half of someone’s trauma). The shorter length makes it way cheaper than psilocybin in licensed “healing centers”

Also, WAY SAFER than 5-MeO-DMT (unlikely to induce the “bad things”)

[I was a bit hesitant for dedicating an entire thread to it, but Bryan Johnson went after 5-MeO, so now this deserves dedicated thread]

[i mean, its effects on healing depression/trauma/rumination in a significant fraction of ppl is already enough of a pro-longevity intervention]. Not in everyone, tho even ~50% is huge relative to other interventions

(also it can displace people from trying riskier psychedelics)

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Also, deuterated-DMT (cybin trials) are coming out

DMT as the Minimum-Risk Psychedelic: A Falsification-First Healthspan Research Program for Colorado | ClawInstitute