It is the central component of ayahuasca, so it is legal in many South American countries + Colorado (where DMT dosing centers will open up next year, and reduce A LOT of the friction b/c you often need an icy bong to vaporize it safely). AND you can try it half-legally in Portugal.
In Colorado - starting June 1, 2026, the Natural Medicine Advisory Board can allow DMT, ibogaine, and mescaline in licensed healing centers
It is also shorter than other psychedelics, making the downside risk way lower than most of them (and safer for time-compressed people to take them slightly more frequently). Some people really heal from it (I know bc I once cohosted a DMT party and it cured half of someone’s trauma). The shorter length makes it way cheaper than psilocybin in licensed “healing centers”
Also, WAY SAFER than 5-MeO-DMT (unlikely to induce the “bad things”)
[I was a bit hesitant for dedicating an entire thread to it, but Bryan Johnson went after 5-MeO, so now this deserves dedicated thread]
[i mean, its effects on healing depression/trauma/rumination in a significant fraction of ppl is already enough of a pro-longevity intervention]. Not in everyone, tho even ~50% is huge relative to other interventions
(if easily available, it can displace people from trying riskier psychedelics)
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Also, deuterated-DMT (cybin trials) are coming out
[when cybersecurity attack surfaces are all around you and could wreck you when you’re not careful on a longer acting psychedelic, DMT becomes one of the few safe psychedelics]
An analysis of hundreds of images from several studies shows how hallucinogenic drugs drive activity in various regions of the brain.
As researchers have sought to demonstrate the therapeutic benefits of mind-altering drugs like LSD and psilocybin “magic mushrooms,” many have struggled to explain exactly how these compounds work on the human brain.
One way scientists have tried to show what these compounds do is by using functional M.R.I. machines to peer into the brains of research participants in the midst of a psychedelic experience. This has produced evocative color images that show a maelstrom of activity as the drugs disrupt patterns of connectivity between brain regions and networks.
But the interpretations of those scans, published in scientific journals, have been inconsistent and even contradictory.
Over the past five years, an international consortium of researchers has tried to make sense of the divergent results by bringing together the data from nearly a dozen brain imaging studies in five countries that have been published since 2012. The studies included more than 500 scans of 267 research participants on five substances: LSD, psilocybin, mescaline, DMT and ayahuasca.
Their findings, published on Monday in the journal Nature Medicine, suggest that psychedelics prompt a welter of activity between regions of the brain that normally operate somewhat independently: the areas that process sensory information like vision, hearing and touch, and those involved with abstract thinking and self-reflection.
The research suggests that psychedelic compounds temporarily reduce the separation between how we think and how we perceive, which could explain the neurological mechanics behind the sensory distortions, mystical experiences and ego dissolution that patients report during sessions.
Understanding these mechanics has become increasingly important as a growing body of research suggests that psychoactive drugs like ayahuasca, ketamine and MDMA can be effective in treating depression, anxiety, post-traumatic stress disorder and other mental health conditions.
Manesh Girn, a neuroscientist at the University of California, San Francisco, and a lead author of the new study, said the results provided a generally accepted reference point for understanding how psychedelics affect the brain and whether these compounds have therapeutic benefits.
“It helps shift the conversation from hype to clarity,” Dr. Girn said. “If psychedelics are going to become part of medicine, we need reliable bench marks for how they actually affect the brain.”