If it’s good enough for Putin, it’s good enough for me. 
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Well, with the death of Dr. Khavinson, it may not have been good enough for Putin. 
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I think things that activate SOX2 encourage autophagy through that pathway. The improved in MMP is attacking aging directly. (I think a reduction in Mitochondrial membrane potential is one of the two basic causes of aging)
Think that first comment was just a verbal “typo”. About 10 seconds later he is very clear that he is talking about average lifespan, see around 1 min 10 second into the clip in your tweet.
Agree on everything else: still early, we need to see publications, this area could be truly transformational, but it may also not practically work and if far, far from proven even in mice yet.
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Appreciate your attention to detail, Neo; I share the same temperament. My caution lies in assessing scientific precision without seeing the data, especially with ambiguity between statements. My original post highlighted this as one of possible scenario (I also mentioned short-lived controls but emphasize there may also be many others).
As an experienced manuscript reviewer for high-impact peer-reviewed journals, I know the devil is in the details. I don’t trust statements made at scientific conferences, particularly those with some ambiguity, until I’ve carefully critiqued the methods and results myself.
I wish more readers could focus on these details, Neo. The next step is to avoid reading too much into the comments until we can evaluate the data ourselves. Hope that helps. Best wishes and stay skeptical.
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Andrew Steele jumps into the discussion on the lure of longevity for the billionaires…
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The use of OSK or OSKM gene therapy, as pioneered by David Sinclair’s laboratory, has emerged as a more effective approach in wild-type rodents [11]. Our research in the hippocampus of aged rats corroborates the advantages of OSKM gene therapy. To date, notable applications of OSKM or OSK gene therapy in vivo include a study on retinal aging in a non-transgenic mouse model [11], enhanced fertility in wild-type female rats via hypothalamic OSKM gene therapy [12], lifespan extension in aged wild-type mice through intravenous OSK gene therapy [26], and the results of our current study. Overall, our findings add to the growing evidence supporting the potential of in vivo Yamanaka gene therapy as a rejuvenation strategy.
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That actually wasn’t too bad. But the new one he talks about from “Ordinary Things” looks even more entertaining. Just Started watching it…so far about longevity influencers…pretty funny.
How to Live FOREVER | Ordinary Guide
Note to @RapAdmin Dave Asprey is right there next to David Sinclair.
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I think this could have been put in the humor section! Too funny!
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Or the Bryan Johnson thread…the long section on him was quite revealing because it kinda poked and probed him more. But in the end, he came off as a little strange but human, vulnerable and likable.
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If you feel that billionaires live longer than average, you’re right.
However only 1 billionaire is currently over 100. Most seem to die in their late nineties. Many are ninety-something.
Overall, only 3.8% of the US population is 80 or older, according to the 2020 census results, compared to 20% of American billionaires on our list. Why does such a larger percentage of American billionaires seem to live past 80 than the U.S. population overall? There could be a lot of reasons, including the fact that wealthy people can afford the best healthcare, personal trainers, and freshest foods.
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Russia’s leader caught on hot mic musing about “immortality” with Chinese ruler.
Russian President Vladimir Putin and Chinese President Xi Jinping were captured privately talking about living to at least 150 years old on the sidelines of China’s massive Victory Day parade in Beijing.
According to audio picked up on CCTV, the two were overheard musing about the possibility of immortality through organ transplants and advanced medical procedures.
“Earlier, people rarely lived to 70, but these days at 70 you are still a child," Xi told Putin according to the translator in Russian.
“With the development of biotechnology, human organs can be continuously transplanted and people can live younger and younger, and even achieve immortality,” Putin replied, according to translation in Mandarin.
“Predictions are, this century, there is also a chance of living to 150,” Xi responded.
North Korean leader Kim Jong Un, who was walking alongside Xi and Putin, appeared to listen carefully to the exchange with great interest.
Putin and Xi are both 72.
Last year, The Times of London reported that Kremlin officials had directed scientists to fast-track anti-aging research, focusing on cellular degeneration, cognitive decline and strengthening the immune system.
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Chinese emperors wishing to be immortal is not a new phenomenon. Yet with current technologies, even Xi will not make it past ~105 at best.
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I’m not concerned about this for at least 50 years.
I’ll be gone in 20 or so years and my kids will be in the 60’s and 70’s by then. So they can figure out what would be best for their children.
All the billionaires alive today will die before any truly radical increase in total lifespan happens. But money never dies, it seeks to live and grow and will transfer to the next ones who have the ability hold that wealth.
For an interesting take on wealth over millennia, read Altered Carbon. The TV show does not do the books justice.
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Extreme wealth typically does not make it past the grandchildren of the billionaires. Billionaires don’t pass on how to preserve wealth, and their progeny spends it all frivolously.
The Rockefeller family’s net worth is approximately $10.3 billion, a fortune spread across more than 200 family members, according to Forbes. While this is a vast sum, it is a fraction of the wealth of the family’s patriarch, John D. Rockefeller, whose 1937 net worth was equivalent to over $300 billion in today’s dollars.
Generational wealth often doesn’t last due to a combination of factors, including lack of financial literacy, poor money management by heirs, lifestyle inflation and overspending, failure to provide clear financial guidance and estate planning, and significant wealth dilution from taxes and inflation. Furthermore, the skills needed to create wealth differ from those needed to preserve it, leading to a disconnect between generations.
Here are the key reasons why generational wealth may not last:
- Poor Financial Literacy and Communication:
Heirs often lack the financial education to manage large inheritances effectively, leading to poor decisions about investments and spending. A significant factor is a lack of open communication about finances within the family, which prevents trust and proper financial wisdom from being passed down, according to Expat Wealth At Work.
- Lifestyle Inflation:
As people receive more money, their spending habits can change, turning luxuries into necessities, a process known as lifestyle inflation. This leads to overspending and the gradual depletion of the inherited fortune.
- Inadequate Estate Planning:
Without a clear estate plan, wealth can be lost through taxes, legal disputes, and inefficient distribution among a growing number of descendants.
- Unforeseen Events and Economic Factors:
Economic pressures, such as market crashes, natural disasters, and high inflation, can significantly erode the real value of wealth over time.
- Different Skills and Goals:
The skills and mindsets required to create wealth are not always the same as those needed to preserve it. Subsequent generations may have different priorities or a decreased motivation to maintain the fortune, contributing to its decline.
- Dilution Through Inheritance and Division:
As wealth is passed down through many generations, it is often divided among a growing number of heirs, which naturally causes the individual share of the fortune to become smaller.
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I wasn’t sure whether to put this here or in the humor section. Xi, Putin and Kim are watching a military parade in China including hypersonic missiles and naval drones (the very latest in killing machines). And they are discussing how to live forever:
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Sounds like irony, only not funny 
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Putin and Xi wanting to perpetuate their pious works…