The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse

This is an interesting paper published yesterday

I think they should not assume the only way citrate gets into cells is via SLC13A5 (aka mINDY - mammalian INDY = “Im not dead yet”). SLC13A5 is only expressed in a few tissues, liver, brain, testes. In the liver particularly it acts to pull citrate out of serum.

Hence if you increase cytosolic citrate by increasing the expression of SLC13A5 you would expect to cut cytosolic citrate in cells not expressing SLC13A5.

Hence from my point of view it is good to confirm that reducing serum and hence cytosolic citrate causes progeria as it confirms my hypothesis.