The Cellular FedEx: Can "Young" Exosomes Deliver Eternal Youth?

#1

In a comprehensive new synthesis of the longevity landscape, researchers from Tabriz University of Medical Sciences, Iran, published in the Journal of Translational Medicine (2025), have effectively declared the end of the “whole cell” era and the dawn of the “cell-free” revolution. The paper, titled “Exosomes in aging and age-related disorders,” tackles the long-standing “parabiosis paradox”—where young blood rejuvenates old mice—by identifying the cargo, not the cells, as the primary agents of youth.

The “Big Idea” is that aging is fundamentally a failure of logistical communication. Senescent cells hijack the body’s delivery network, flooding the system with “pro-aging” exosomes packed with inflammatory microRNAs (like miR-146a) and oxidative stress signals. This creates a contagious “bystander effect” where old cells corrupt their healthy neighbors. The authors propose a radical intervention: intercepting these “death signals” and replacing them with “youth signals” derived from young sources, such as Umbilical Cord Mesenchymal Stem Cells (hucMSCs). By delivering functional mitochondria, NAD+ boosting enzymes (eNAMPT), and anti-inflammatory codes directly into aged cells, exosomes offers a “software update” for the genome without the cancer risks associated with live stem cell transplants.

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#2

Umbilical Cord Mesenchymal Stem Cells Exosomes are available.

Cost around $3,200 per vial, you inject

Or additional cost to have a physician inject.

How many have resources for 3X (1x per month) to try?

#4

No, no and no. This is a stupid and unfeasible approach, sorry. I can write an entire essay about why. But basically, the product is not defined at all. We have no idea what “active” ingredients there are. We have no idea what the risks are. Biologically it doesn’t make a huge amount of sense. The dosing is nonsensical.

@RapAdmin That AI summary has plenty of hallucinations and inaccuracies. Too many for me to individually list.

Also, fun fact, I peer reviewed this paper when it was originally submitted to a higher ranking journal. It must have been rejected and ended up in JTM. And, to be really honest, guys at Tabriz University don’t get to declare the end of cell therapy. The major paper (miR-146a etc) that they’re talking about is Chen et al, Nature Aging, which I reckon is only true for B6 mice. My lab has tried to replicate the major findings and couldn’t even detect some of the same miRNAs.

This field is VERY immature, and I see the tide turning against exosomes/EVs now. They’ve been over-hyped for several years.

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#5

OK - good input. I’m going to leave the initial post up though, because “exosome” therapies are becoming increasingly popular and interesting to people, and your post is a good reality check for people.

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