(Note: the “109%” figure is of “Remaining life” (and the mice were old when it was implemented). It was only about 7% total lifespan extension, which is very moderate. See this thread and this thread discussing this research. I’m still optimistic about this research, but the results so far have not been as good as billed, in my opinion.
At LEAP, Dr. Noah Davidsohn of Rejuvenate Bio tells us how he is fighting against our inevitable decline.
Dr. Noah Davidsohn of Rejuvenate Bio and his team have lit a beacon of hope in the fight against aging. His team have successfully extended the healthy lifespan of mice by a staggering 109%. This translates to roughly doubling the lifespan of an 80-year-old human, a prospect that has sent ripples of excitement and trepidation through the scientific community and beyond.
This achievement, Dr. Davidsohn explains, builds upon previous research from the Sinclair Lab, where he played a key role in reversing the aging process in the optic nerve of primates, “We’ve since modified that technology, and we’re able to deliver it systemically to mice to show age reversal and lifespan extension. So it is an extension and addition to that initial work,” he says.
The underlying mechanism hinges on a fascinating concept called “epigenetic programming.” As we age, our genes become dysregulated, with some genes expressing themselves excessively while others fall silent. Dr. Davidsohn’s approach corrects this dysregulation, essentially resetting the cells to a youthful state, not just in appearance but also functionally, “It’s not just increased health, you’re actually creating younger cells that will behave as if they were 25 again,” he says. The implications for human health are nothing short of transformative. Dr. Davidsohn anticipates clinical trials within the next few years, mirroring the timeline of the Sinclair Lab’s research.
Full story: The battle against the aging process - WIRED Middle East