You’re saying this is a risk posed by l-citrulline? Based on what?
Not an expert. Just what came up when I was trying to finds ways to optimize my ADMA levels and that aspect of endothelial health (and I decided to hold off on L-Citrulline and try some other things first).
Just did a quick Gemini 3 prompt and it came up there again so you can easily research it if you are interested.
Just for the hibiscus tea drinkers, I tried adding citruline malate to my tea this morning and I found that it really enhanced the flavour.
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I add it to real lemon juice and water over ice, with glycine as a sweetener. Tastes good.
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so far 3 weeks 5 grams twice a day. I have a large bottle to use so we’ll see
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Citrulline malate is the best way to make faux lemonade. I add it to a decaf fruit tea with glycine, and it’s delicious. I’ve also started adding tart cherry extract as well which enhances the flavor further. Since I drink it before bed, the extra melatonin enhancement seems to be a perfect complement to the citrulline and glycine.
I feel like I’m becoming a culinary longevity afficianado. 
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Any measurable benefits?
none at all - was hoping to improve pulse wave velocity but that has gotten slightly higher. Maybe I’m just consuming filler. My BP has not changed either but has always been 104/68
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The Withings Body scale measures this, mine is 5 years lower than my chro-age. I’m going to try L-citrulline to see if it improves.
I feel like my Manganese experiment over the past 2 years is helping to keep my PWV lower than my age and I did see it go down over the first year but it seems to have slowed in the past year,
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Do you have a recipe? I have a few kg of citrulline malate but I just cannot stomach it unless I add in bicarbonate otherwise it’s just too acidic
Use the glycine to balance it out. Trial and error based on how much tea you make.
What is your manganese experiment? I recently learned I have a SOD2 genetic deficiency, which is a manganese-dependent enzyme.
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Since Manganese is a two edged sword, one beneficial the other harmful, this is one that should not be used at high doses. I have no clue how this mineral would relate to a genetic SOD2. deficiency so I’ll ask my friend Perplexity. That will be at the end of the attached PDF.
It’s important to understand the “risks” of too much Mn, the first few sections explain that risk.
Apparently supplementing with Mn is not going to be of much benefit to this condition, unless one is deficient.
I supplement 10mg per day, not sure how much I get in my diet. This is on the high side but there are 40mg doses available, not sure why though.
My objective is to watch my PWV (pulse wave velocity) and see how that is going. So far my PWV is below my chronological age (64 vs 70years). I use a Withings Body Cardio scale for this, that is the only one I believe can do this measurement. I also have a Renpho Morpho 8 lead scale to collect other data.
PWV is considered a better measurement that blood pressure for evaluating arterial condition.
To date there are no clinical studies in humans to evaluate if optimum Manganese levels affect arterial plaque and arterial stiffness, only extreme high doses in mice demonstrate this effect.
manganese, arterial plaque, preclinical and clinic (1).pdf (928.1 KB)
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Thanks for the info. I agree, 10 mg of Mn seems high. You might want to investigate further as my reading suggests that is potentially problematic.
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Not terribly concerned at this dose 5 days a week and every few months I take a couple weeks off. If you read the PDF, you can see I’ve done more homework on this than most people.
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Interesting, this:
ONE DOSE Of This Cheap Supplement Repairs Leaky Gut (New Study)
It references this 2014 paper (so, not a new study):
Conclusions: Pre-exercise L-citrulline intake preserves splanchnic perfusion and attenuates intestinal injury during exercise in athletes compared with placebo, probably by enhancing arginine availability. These results suggest that oral L-citrulline supplementation is a promising intervention to combat splanchnic hypoperfusion-induced intestinal compromise.
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