Even better - but I’m not sure. They’re rare enough for me to not worry too much. Being aware will make me vigilant and I’ll stop if there are any signs.
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See the full list here: and, from For Researchers | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation
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I had pretty bad seasonal allergies as a child and was prescribed monteleukast/Singulair. I don’t think I was on it that long, but my allergies went away even after I stopped taking it.
A couple years back I convinced an NP to prescribe me monteleukast for symptoms of stomach inflammation that I’d been dealing with for two years at that point. I only took it for a month or two because any benefits seemed to be marginal, so I still have a huge bottle of monteleukast in the cabinet.
My lady has pretty bad allergies so I’ll give her some now and then. It gives her rapid relief but doesn’t last for long. I’m aware of the black box warning, but I never noticed any neuropsychiatric changes from it. Although I guess given their rarity that’s not surprising.
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Thank you for the reminder about montelukast. I’ve been taking it for years for the generalized anti-inflammatory effect.
I have a history of asthma so my insurance pays for it. However I think it fell down behind a counter and I haven’t been taking it lately. I need to get back on it.
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Have ordered some from India. From your personal experience, have you noticed anti inflammatory effects apart from lungs?
Also look into Plasmalogens, particularly the high dose version (900mg/dose) sold by Prodrome Sciences, discussed in various threads here : Breaking Autism Q&A with Dr. Dayan Goodenowe: Insights and Solutions for Families Living with Autism (free for this month!) discusses plasmalogens and neuroinflammation!
I just ordered the $500 Plasmalogen blood test kit for myself and my wife (64 & 71) and plan to use Plasmalogens if deficient along with Montelukast 2x10mg/day that is on order from Indiamart.
For your mother who already has neurological symptoms, I would postpone the blood test and do the 1 month loading dosage of 3600mg/day for both versions (Omega-3 and Omega-9) : symptoms should improve within that time period if the issue is Plasmalogen deficiency. Based on list price this is $36/day (for 7200mg/day total), but you can find practitioners selling at discounts that reduces that to $21.60 /day (+ sales tax). The maintenance dose after 1-3 months of the loading dose would be 1/4 of that, $5.40/day (less if you don’t need both versions, based on the $500 blood test).
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@RapAdmin, A long but interesting paper that I’ll bring up with my PCP. I take a couple of antihistamines for sleep, such as Benedryl, whose long-term use has been implicated in cognitive impairment. Montelukast may be effective as an antidote.
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It took several months but I finally started on montelukast today. My pcp prescribed it for me at 10mg/day. I’ll let y’all know if I notice anything positive or negative.
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From the first link you posted, RapAdmin.
The website owner clearly spent a lot of time collecting information, and admittedly I haven’t looked into this drug much, so I don’t want to draw any conclusions. But this does make me wonder how reliable of a source that website is?
By the website owner:
“This is a summary of the email I sent to the Advisory Council on Alzheimer’s Research, Care, and Services. The Advisory Council advises the Secretary of the US Department of Health and Human Services on Alzheimer’s affairs.” […]
"> [Summary of my email]
My name is XXXXX and I retired from the Department of Veterans Affairs Atlanta Regional Office in 2009, where I worked in the accounting and finance section. I have been living in Ghana for the past 14 years.
There is an urgent need to investigate the results of the Emory University montelukast Alzheimer’s clinical trial.
Emory montelukast Alzheimer trial
ClinicalTrials.govThe preliminary results on the Emory trial for montelukast were posted in December 2023 in clinicaltrials.gov. The results were historic in that it marked the first time in FDA clinical trial history that early Alzheimer’s and mild cognitive impairment (MCI) participants showed cognitive improvement over a year’s time. However there was a problem with the results. The placebo group improved in the cognitive tests, and the montelukast treated group declined. The placebo group also improved in CSF amyloid and tau measurements.
From the results, it is evident that the montelukast and placebo medications were switched between the groups. It appears that the placebo group was given the montelukast medication, and montelukast group was given the placebo pills. It appears to me to be deliberate.
It is important to investigate the switching of medications and find out who was responsible. The FDA should also investigate which medication individual trial participants actually received. That way, the correct results could be reconstructed."
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If that is true, it is a big WOW and contributes to the lore of medical conspiracy theories that effective drugs are suppressed.
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Interesting news on this drug:
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These warnings as well could add fire to the conspiracy theories. A cheap drug with multiple indications…
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From the article, “Since it was first authorised in the UK in 1998, approximately 44 million prescriptions of montelukast have been issued. During this time, there have been 1,223 reports of suspected neuropsychiatric adverse reactions.”
I didn’t do the math but this seems pretty underwhelming. The 1,223 people who experienced issues would probably disagree. It’s certainly always good to be aware of potential problems.
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After taking montelukast for many years for mild allergy-related asthma, I weaned myself off about 2 years ago for this reason. Had no recurrence of the asthma symptoms, either, maybe due to all the other supplements I was taking.
I was just thinking about this today. There’s definitely nothing negative to report. I don’t know that there is anything I can specifically attribute to montelukast though either. I’m happy I’m on it though and I’ve been feeling good in general for the last couple of months since starting it. Thanks for checking.
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Thanks! You have swayed me… I’m going to speak to my doc about it.
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Best wishes to you! Please let us know how it goes.
I took it for allergies for a few years. I don’t remember why I stopped, but I had no issues and I’m prone to depression.
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Montelukast, an available and safe anti-asthmatic drug, prevents maladaptive remodelling and maintains cardiac functionality following myocardial infarction
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