Has anyone looked into this drug in-depth? It looks interesting.
https://www.sciencedirect.com/science/article/abs/pii/S0014299922001534
More resources: https://mylongevityjourney.blogspot.com/2023/04/leukotriene-inhibitors.html
and, from For Researchers | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation
Montelukast-Cognitive-Vitality-For-Researchers.pdf (329.3 KB)
Less than $0.02/tablet from Indiamart.com. Even in USA, Goodrx.com reports 90 tablets cost under $15.
You need 2-3 tablets/day for the brain and prostate anti-inflammation benefits.
I’m familiar with it as an asthma controller and always thought in the back of my mind that it seemed potentially promising for many reasons but tbh I never took the time to look into it more. This write up is a goldmine. I saved it and will be giving serious consideration to adding it to my personal longevity stack in the near future. Thank you for the information sir!
Thank you! My 83 year old mom is having memory issues. I will take a look. Are there any other medications I should be investigating?
My 81-year-old mom has had strong results on Intermittent Rapamycin Therapy(GFJ-EVOO-2mg once per week).
She was displaying short-term memory problems. 18 months on Rapa, some observational improvement, but not a cure.
Some risk of mental health problems (see incidences below), but looked like a good risk reward to me (I have neuroinflammation from MS).
Neuropsychiatric reactions with the use of montelukast | The BMJ
From Montelukast (Singulair): reminder of the risk of neuropsychiatric reactions - GOV.UK (www.gov.uk)
Reported neuropsychiatric reactions
A range of neuropsychiatric reactions has been reported in association with montelukast. Among these are: sleep disturbances, depression and agitation (may affect up to 1 in 100 people taking montelukast); disturbances of attention or memory (up to 1 in 1,000 people); and very rarely, hallucinations and suicidal behaviour (up to 1 in 10,000 people). See the Summary of Product Characteristics and the Patient Information Leaflet for full details.
But for me the benefits: potentially interesting for remyelination:
A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases
Aren’t these side effects predominantly associated with children?
Even better - but I’m not sure. They’re rare enough for me to not worry too much. Being aware will make me vigilant and I’ll stop if there are any signs.
See the full list here: and, from For Researchers | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation
I had pretty bad seasonal allergies as a child and was prescribed monteleukast/Singulair. I don’t think I was on it that long, but my allergies went away even after I stopped taking it.
A couple years back I convinced an NP to prescribe me monteleukast for symptoms of stomach inflammation that I’d been dealing with for two years at that point. I only took it for a month or two because any benefits seemed to be marginal, so I still have a huge bottle of monteleukast in the cabinet.
My lady has pretty bad allergies so I’ll give her some now and then. It gives her rapid relief but doesn’t last for long. I’m aware of the black box warning, but I never noticed any neuropsychiatric changes from it. Although I guess given their rarity that’s not surprising.
Thank you for the reminder about montelukast. I’ve been taking it for years for the generalized anti-inflammatory effect.
I have a history of asthma so my insurance pays for it. However I think it fell down behind a counter and I haven’t been taking it lately. I need to get back on it.
Have ordered some from India. From your personal experience, have you noticed anti inflammatory effects apart from lungs?
Also look into Plasmalogens, particularly the high dose version (900mg/dose) sold by Prodrome Sciences, discussed in various threads here : Breaking Autism Q&A with Dr. Dayan Goodenowe: Insights and Solutions for Families Living with Autism (free for this month!) discusses plasmalogens and neuroinflammation!
I just ordered the $500 Plasmalogen blood test kit for myself and my wife (64 & 71) and plan to use Plasmalogens if deficient along with Montelukast 2x10mg/day that is on order from Indiamart.
For your mother who already has neurological symptoms, I would postpone the blood test and do the 1 month loading dosage of 3600mg/day for both versions (Omega-3 and Omega-9) : symptoms should improve within that time period if the issue is Plasmalogen deficiency. Based on list price this is $36/day (for 7200mg/day total), but you can find practitioners selling at discounts that reduces that to $21.60 /day (+ sales tax). The maintenance dose after 1-3 months of the loading dose would be 1/4 of that, $5.40/day (less if you don’t need both versions, based on the $500 blood test).
@RapAdmin, A long but interesting paper that I’ll bring up with my PCP. I take a couple of antihistamines for sleep, such as Benedryl, whose long-term use has been implicated in cognitive impairment. Montelukast may be effective as an antidote.
It took several months but I finally started on montelukast today. My pcp prescribed it for me at 10mg/day. I’ll let y’all know if I notice anything positive or negative.
From the first link you posted, RapAdmin.
The website owner clearly spent a lot of time collecting information, and admittedly I haven’t looked into this drug much, so I don’t want to draw any conclusions. But this does make me wonder how reliable of a source that website is?
By the website owner:
“This is a summary of the email I sent to the Advisory Council on Alzheimer’s Research, Care, and Services. The Advisory Council advises the Secretary of the US Department of Health and Human Services on Alzheimer’s affairs.” […]
"> [Summary of my email]
My name is XXXXX and I retired from the Department of Veterans Affairs Atlanta Regional Office in 2009, where I worked in the accounting and finance section. I have been living in Ghana for the past 14 years.
There is an urgent need to investigate the results of the Emory University montelukast Alzheimer’s clinical trial.
Emory montelukast Alzheimer trial
ClinicalTrials.govThe preliminary results on the Emory trial for montelukast were posted in December 2023 in clinicaltrials.gov. The results were historic in that it marked the first time in FDA clinical trial history that early Alzheimer’s and mild cognitive impairment (MCI) participants showed cognitive improvement over a year’s time. However there was a problem with the results. The placebo group improved in the cognitive tests, and the montelukast treated group declined. The placebo group also improved in CSF amyloid and tau measurements.
From the results, it is evident that the montelukast and placebo medications were switched between the groups. It appears that the placebo group was given the montelukast medication, and montelukast group was given the placebo pills. It appears to me to be deliberate.
It is important to investigate the switching of medications and find out who was responsible. The FDA should also investigate which medication individual trial participants actually received. That way, the correct results could be reconstructed."
If that is true, it is a big WOW and contributes to the lore of medical conspiracy theories that effective drugs are suppressed.
Interesting news on this drug:
These warnings as well could add fire to the conspiracy theories. A cheap drug with multiple indications…
From the article, “Since it was first authorised in the UK in 1998, approximately 44 million prescriptions of montelukast have been issued. During this time, there have been 1,223 reports of suspected neuropsychiatric adverse reactions.”
I didn’t do the math but this seems pretty underwhelming. The 1,223 people who experienced issues would probably disagree. It’s certainly always good to be aware of potential problems.