A pioneer in developing “next generation” probiotics and postbiotics, announced today that the Patent Trial and Appeal Board (Board) of the United States Patent and Trademark Office (USPTO) has issued a decision in a patent interference involving the probiotic Akkermansia.
In that decision, the Board found that the inventors of applications licensed to The Akkermansia Company — Cani et al. — were the first to file a patent application related to treating a metabolic disorder such as obesity with the oral administration of Akkermansia, before Kaplan et al., Pendulum’s Therapeutics patent application was rejected.
@sml491010 What is the reason that pasteurized (dead?) akkermansia bacteria help the gut? Does the product contain metabolites from akkermansia that feed the gut lining? I get that supplements containing live akkermansia might not get through the stomach alive either but why does the dead bacteria help? This question probably applies to all probiotics. Thanks.
Kaplan fails to persuade us that its inventors conceived of or reduced to
practice an embodiment of the count before Cani’s priority date of November 19,
2012. Accordingly, we deny Kaplan Motion 3, arguing for priority as to the count
Akkermansia muciniphila (A. muciniphila) is a promising probiotic candidate owing to its health-promoting properties. A previous study reported that the pasteurized form of A. muciniphila strains isolated from human stool samples had a beneficial…
** 5. Conclusions**
Overall, our findings clearly show that with the use of the pasteurized form, there was no loss of therapeutic potency of A. muciniphila, compared to its live form.
Recently, Akkermansia muciniphila an anaerobic member of the gut microbiota, has been proposed as a next-generation probiotic. The aim of this study was evaluation of the effect of alive and pasteurized A. muciniphila on health status, intestinal…
In conclusion, the above our outcomes displayed that A. muciniphila improved body weight, plasma biochemical and inflammatory markers, and morphology of vital tissues. The administration of both alive and pasteurized A. muciniphila , significantly promote gut, adipose, and liver health by modulating immune response and lipid metabolism as well as intestinal homeostasis by improving gut barrier functions and intestine microbiota composition in the study groups. According to better health effects of pasteurized A. muciniphila , use of the pasteurized form as a new strategy seems to be a valid, safe, and potentially more cost-effective medication to improve the host’s health and reduce the risk of metabolic disorders.
@JuanDaw thanks. Do you have any idea how a dead bacteria can help my gut? Does it come back to life? Does the dead bacteria contain metabolites that my gut lining or other bacteria likes to eat, or kills bad bacteria, or what?