Taking rapamycin with high triglycerides

As a matter of precaution before starting taking rapamycin and acarbose, I had blood work done recently. Everything looks good, except is seems my triglycerides are kind of high for my age. Instead of being < 90 mg/dL, my levels are around ~110 mg/dL. My other lipid levels are good, but still on the higher end:

I know taking rapamycin is known to disregulate lipid homeostasis, so I was concerned about this. I will probably build up to 3mg/week rapa and do another blood test in a year.

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I don’t eat a lot of meat most days (instead mostly eggs) because I don’t like handling meat while cooking lol. But not vegetarian.

Keep in mind afaict they discriminate early 20s levels of these biomarkers against adult biomarkers (I’m in my early 20s), so what could be a healthy level later in age might not be healthy for me right now if that makes sense.

Cut down on your carbs, if your glycogen stores are full all the carbs you eat are converted to triglycerides. You could also add in some hiit (you carry around 2000 kcal worth of glycogen so that’s a lot of exercise ) and/or fasting to empty your glycogen

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This is great information! I’ve never heard that carbs can become triglycerides. My triglycerides are a little high but I do have a sweet tooth.

Tangentially on that point, I’ve heard that appetite can be affected by the gut microbiome—that you think you’re hungry for something, but it’s the gut bacteria that are hungry and are sending signals to your brain.

On that theory I’m consuming a lot more probiotics, mostly from food but also in capsule form from time to time. Also lots of fiber, both from food and powder.

Hopefully this will help lower my hunger for carbs, lower my carbs and maybe triglycerides too.

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By taking acarbose I’m hoping it indirectly lowers my triglycerides and other cholestrol markers since it prevent the breakdown of complex carbs into glucose, but there is probably some biological context I’m missing here right?

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Our bodies do not like to waste anything but as storage of carbs is limited to around 400g (100g in the liver, the rest in your muscle) the rest gets converted to fats. Amino acids of course too but they are virtually impossible to overeat

For probiotics try finding some real kefir grains, kefir is very easy to make, very satiating and has the best probiotic culture

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Good news– my doc said that my levels are normal and could be dependent off of the food I ate the day before. Now I’m less worried!

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Thinking this through… some people get raised triglycerides while on rapamycin. If Rapa tells cells to ignore the nutrient rich environment and to clean-up and repair instead of growing and building, then people who eat normally on rapa days may end up with excess calories in the system that are turned to fats. Does this make sense? Seem likely? Does this suggest that we should eat less on dosage days?

wouldn’t necessarily jump to that conclusion. in the ITP both rapa and control groups of mice were fed the same way and there was still the lifespan effect. It might not be the calories that matter, but what you eat instead*

*I would read some of these papers that are in the following link before I state anything remotely conclusive. Haven’t read any of them myself but seems like they offer differing viewpoints to whether or not rapa increases cholestrol/triglycerides: https://elicit.org/search?q=does+rapamycin+increase+fat+stores&token=01GJFRW5KGGCZA4N228A43X4FJ

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Citation? I know the opposite. If you eat carbs alone, it will not get converted and stored as fat.

That’s common knowledge in physiology and just the only explanation possible in the light of the laws of thermodynamics: we don’t excrete glucose normally and we can only store 400g of them so the rest we must store otherwise

Not sure what you mean by this. Is Glycogen Glucose?

Common knowledge is not good science. What is assert without evidence can be dismissed without evidence.

Lots can happen with carbs after ingestion, like trafficked as trigs.

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Do TGs even damage the cell, especially if they are elevated in isolation? FFAs are worse.

Also doesn’t the composition of TG matter (eg olive oil)?