New poster here. I have a question: I have been prescribed low dose (250 mg daily) of long term (12 weeks) clarithromycin for on-going inflammation of my sinuses. According to the data, “Clarithromycin inhibits cytochrome P450 3A (CYP3A)-mediated drug clearance by forming a metabolic intermediate complex (MIC) with CYP3A, thus contributing to increased blood levels of sirolimus.”
I was doing weekly 4 mg of rapamycin prior to my prescription of clarithromycin but stopped it due to its interaction with rapamycin. I read that 250 mg of clarithromycin will be completely eliminated from the body 16 to 22 hours after taking.
Can I still safely take my 4 mg weekly dosis of rapamycin if the day I take it I skip my daily clarithromycin dose?
Any thoughts or input will be greatly appreciated.