Yeah, as I said in that thread, I’m staying away from this class of drugs, not having ED, HT, T2DM or CVD. The MR preprint was the nail in the coffin for me, although the relatively high prevalence of eye issues (11%) was also not encouraging. YMMV.
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Very interesting. A little hard to interpret overall, but the MR study in particular is thought-provoking for sure. Thanks for sharing.
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This has been talked about all over X in recent days.
PDE5’s mechanistically could prevent cancer with additive effects when combined with a statin
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Then don’t mess with Melanotan !
Melanotan 2, specifically. Not an issue with melanotan 1.
David sinclair
Note: the Rapamycin dose is 1mg daily
https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.802/8745417?login=false
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Good to see some dosing protocols from professionals.
My urologist put me on tadalafil years ago for vascular health. The side effects aren’t too bad every morning either… if you are a dude … you know.
My rapamycin dose is 6 mg rapamycin weekly… straight…no GFJ or VOO. 3 months rapamycin… one month HGH. Repeat.
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Another Rapamycin study showing 1mg daily yields benefits. At this point, we might have more positive human data with that dose than we do with intermittent (not that we have a large sample size to go off of).
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I have held the view that if you want to “tame” the hypoactive mTor (per Dr Kennedy) as we aging, a daily dose with some breaks indeed may be better.
I would just follow my NLR ratio to decide if I am not overly depressing my immune function.
To have weekly dose means creating a rebound every time, does the rebound increasingly higher?
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Thanks for the info on your experiences. I just started sildenafil recently. Have 50 mg tablets that I break in half for once-a-day dosing (25 mg). I have started taking it only on workout days for the benefit there. I have started buying it from Friday Plans that you constantly see ads on TV. About a buck or so a pill. Not sure what you pay for stuff from India, but would be interested in knowing.
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Damn… that’s a let’s get jiggy dose!
I take 5 mg daily… and get plenty of effect.
He was talking about Viagra, not cialis. 25mg is a low dose of viagra
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I don’t know why I keep doing this to myself but whenever I attempt to start taking Tadalafil again, my eyes get extremely red and it’s like that all day. I am surprised more people don’t mention that side effect. I am usually not an outlier when it comes to certain side effects.
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If I was interested in tadalafil (I’m definitely not!), this is what would stop me dead in my tracks - the pretty high risk of eye problems, and even hints of ototoxic effects (hearing). Even if you don’t experience diagnosable severe pathology, it may still put detectable strain on your eyes (10% of users), and who knows what is happening that you’re not feeling in the moment - no thanks. YMMV.
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I have looked at the pleitropic effects related to brain vasculature this one provides, and according to AI, the risk of hypotension doesn’t make it worth it for me. My BP is about 99/65, and a combination of SGLT2 inhibitor + GLP-1 RA + Rosuvastatin + Ezetimibe is already providing microvascular, endothelial, and neuro-inflammatory protection.
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Actually, if you take this drug with a low BP, it might lower your BP inside your heart and might cause a massive heart attack. This one to be prescribed under a doctor’s supervision that knows what they’re doing IMO (checking medical history & other prescriptions).
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Key point. If your current stack already covers a given area, there is absolutely no reason to take onboard another agent that addresses the same area, unless you are doing a substitution because the new agent is clearly superior (stack re-adjustment). You are increasing risks with no advantage. In my business we call that “a hat on a hat” - if you are already wearing a hat there is no point in putting on another one, you can only make it worse. This is a kind of plague in the biohacker space - constant reports that some drug or other has “a benefit” and folks rush to take it without asking whether they need that “benefit”, even if the benefit is real. Establish your stack with the best evidence and fitted to your requirements, and if another drug comes along, ask why you should take it (my stack is like a giant tanker - very slow to change direction, it takes me a long time to take a drug aboard, and a lot of evidence to make a change). YMMV.
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