Supplemental alkaline phosphatase targets the gut barrier to prevent aging

I’m going by Michael Lustgarten’s book on the microbial burden. Also the biomarker optimizer graphs:

https://biomarkeroptimizers.com/tools/test-results-analyzer/

Lustgarten says when serum ALP is more than 48 it increases your all cause mortality. He shows a graph that looks a lot like the one in biomarker optimizer. The higher the worse.

Intestinal ALP decreases with age, letting more LPS through the gut into the serum. As serum LPS increases, the body increases serum ALP to take care of it. ALP gets rid of LPS.

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I don’t think Michael Lustgarten puts too much weight on any particular test, and the majority of the information is about observational studies, not RCTs. BTW can you point to his video about ALT?
The graph you point to is based on an observational study only.
“Age and sex variation in serum albumin concentration: an observational study”

Sorry, I think I saw that here too not that long ago but can’t find it now.

I don’t know for sure but I like that he sticks his neck out a bit and tells the reader what he thinks based on observational studies. I learned a great deal from his book and even if it’s wrong at least I know the characters a little better. LPS, ALP, CD38,NAD, LL-37. That article you pointed to said they don’t know what it does. He says if you work on barrier function and reduce microbial burden it will go down. Anything over 48 is bad. So at least I have an idea what to do.

It’s fine to want to adjust all of our health parameters to the best possible levels, but ALT is not high on my list.

As you can see ALT isn’t even on the Levine-based age spreadsheet calculator.

Also, ALT is not found as one of the parameters on the Aging.Ai, 19 parameter input calculator.

(As, a side note: Why I am not big on CRP measurements unless you are sick and it is being used to help with a diagnosis) “C-reactive protein value can change by orders of magnitude in the presence of a wound or infection.”

FWIW, (Maybe, posted before?):

Ranking the influences in order as calculated by @JGC Retired Professor of Physics 4 yrs ago.

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ALT is alanine transaminase, not to be confused with ALP alkyline phosphatase. Alkyline Phosphatase is in the levine calculator. And I don’t really understand the list you put out but it looks like it’s worth more than CRP.

I’ve been talking about ALP.

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Don’t know enough but your blood test might be different from what you want in your micro biome

See et this

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Anyone have any experience on whether the peptide BPC157 might help ALP with fighting leaky gut?

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You’re sure about this? My recent result was 40 and flagged as LOW. I read deficiencies in magnesium and/or zinc could cause that, even though I consume plenty of both.

I’m not a doctor. I read about this in Michael Lustgarten’s excellent book “Microbial Burden and what you can do about it”. I’m sure the microbial burden is not the only thing that affects AP. Google lists protein deficiency and a couple diseases as well. If these things are ruled out then that leaves really good news about your microbial burden.

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Update, I asked him and this was his response

“< 48 for ALP is associated with lowest all-cause mortality risk, so you’re likely good there

Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis - PubMed

So thank you for bringing it to my attention @Bicep . I’m not so worried anymore

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Have you tried supplementing with these? It looks like one of the safest approaches right now in terms of longevity.

I was hoping someone had tried with available current IALP:

Unfortunately, it appears that Synthetic Biologics (now Theriva Biologics) has abandoned further work on this asse. It’s not currently listed in their pipeline, and a press release from November mentions " lower expenses related to our Phase 1a clinical trial of SYN-020 which has completed".

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An update to this thread. This article from 2024 brings forward the theoretical framework that challenges the mainstream theory of ageing. For those not familiar with the term “smurf” in ageing - they have found that when flies are fed with food that contains a blue dye, then 2–3 days before the death, the fly turns blue. Therefore, the name smurf. This smurf phenotype is due to the breakdown of the intestinal barrier, a leaky gut. They don’t say that “leaky gut” is causative of an impeding death, but there is a very strong correlation between the smurf phenotype and an imminent death. Now they try to find signals that precede the smurf phenotype.

"It is demonstrated that the smurf phenotype is a harbinger of death across species, allowing for the identification of individuals about to die from natural conditions 2–3 days prior to death. As time passes for a non-Smurf, its gene expression becomes noisier until it reaches a point—an hypothetical “Smurf Transition Point” yet to be characterized—at which individuals undergo an abrupt modification of the transcriptome, reminiscent of the “transcription hallmarks of ageing” leading to a general stereotyped collapse "

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How unfortunate. I’ve never managed to even get mine into the reference range in as long as I’ve been checking. No amount of magnesium or zinc helps. It’s very perplexing. I am truly at a loss as to why my ALP is always so low.

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It’s kind of cheating I know, but TUDCA will fix that. I was only taking it a few times a week and it dropped 40 points.

The article is talking about Intestinal Alkaline Phosphatase, you are talking about serum Alkaline Phosphatase. They are really different!

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Oops sorry I was skimming

Thanks for letting me know there is a distinction. I was not aware!

I have always had low serum ALP and have never been able to figure out if that’s a problem/concern or not. If you learn anything more please share!

My understanding is that low serum ALP is good. This study shows lower is better and all the way down:

https://sci-hub.ru/https://doi.org/10.1093/ije/dyt192

I use this when I want to know what’s good in lab values:

https://biomarkeroptimizers.com/tools/test-results-analyzer/

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