Supplement Companies - The Good and The Bad (Reference)

Thanks, I’ve looked up the Hansen site, I remember the investigation from Andrea Meier of NUS, apparently she bought all those NMN samples out of her pocket.
Do the bottles come with dosing spoons?
I agree that MCS looks promising and they have a wide choice of products.

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If you buy from Hansen they will give you 1 or more spoons, if that is what you like.

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I also have used them ( they asked me how many dosing spoons I liked and still using these) for several of their supplements , have not yet tried their NMN ( I say used since am on a break as I took so many supplements at the end it felt it got out of hand ).

for NMN I only used Agescience since I got good effects with that immediately (except for them , I tried Purovitalis once for NMN and that did not seem to have the same effect ).

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Too bad they don’t give the names of the brands: Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim | GeroScience

I guess they were afraid of being sued…

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I found a manufacturer that provides ingredients to companies with the business of selling quality products, I try to stay away from Chinese “quality”. . Today I found Bonerge Lifescience. At first glance, it looks like they have the production facility in Ontario CA , USA. They could be a promising alternative to relying on brands for which we don’t know where they buy their ingredients. China? If they are okay, then the task at hand will be to trace the brands that use their ingredients.

Does anybody know more about Bonerge Lifescience?

ABOUT BE - bonerge

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It appears most supplement companies do source from China. That seems almost unavoidable, and it’s not much different for drugs. A significant portion of the active pharmaceutical ingredients and raw materials used in drug manufacturing come from China.
For example: a supplement company was mentioned in this thread that sells supplements for (frankly) outrageous prices. I noticed they source their ingredients from a specific EU-company/vendor, and (having been in contact with that company/vendor years ago) I know they source from China. But they do seem to test their ingredients in an external lab. The latter is the thing I mostly try to keep in mind, as well as potential consumer test results, as I feel it’s nearly impossible to avoid ingredients from China.

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Bonerge looks reasonably good based on a look at their website and a google search. However they may be China based. But if, as they say, they do high quality testing with high standards that may be the best way to maintain competitive pricing. I would like to see third party testing and COAs for every batch. These links say that their big new factory and lab are in China. They are starting human clinical trials on some of their supplements - berberine and fisetin. They also have Urolithin A.

https://www.streetinsider.com/Business+Wire/Bonerge+Lifescience+opened+its+new+manufacturing+facility+to+further+support+the+innovation+of+its+branded+ingredients/22036073.html

https://www.marketwatch.com/press-release/bonerge-initiates-the-human-clinical-trail-plans-for-glucosober-r-dihydroberberine-and-befisetin-r-fisetin-d9cee1ba

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https://x.com/joshwhiton/status/1862545385446608930

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Very concerning. We should probably only buy from the company directly…

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They took down that X page. What did it say that was concerning?

The guy was mentioning a supply chain issue with a supplement he bought: he received a fake one from Amazon because Amazon replaced the one from the brand with another one from a fake supplier. I don’t know why he deleted. His story might not be true but this can definitely happen with supplements. The supply chain for pharmaceuticals is way more controlled.

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Been a member there for several years, excellent information, well worth the investment.

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After several years of buying supplements and measuring quality/cost, these are the top supplement companies I use from most frequently to least.

  1. Bulk Supplements - high quality and cheap prices.
  2. Nutricost - cheap prices and good quality.
  3. NOW - high quality and reasonable prices.
  4. DoNotAge - Very high quality and reasonable for some supplements such as CA-AKG and NMN.
  5. Double wood - mostly just for lithium orotate.
  6. Horbaach - for their prostate supplement.

That’s pretty much it. The vast majority of my supplements come from the first 3 vendors.

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I use :

BulkSupplements
Hansensupplements
Lifeextension
NOW

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This is one of the biggest reasons why I don’t trust ingesting anything from Mainland China.

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Yes, same here. I also do not drink tea from china. Tea plants do absorb heavy metals from the soil, and these metals can end up in the harvested tea leaves. Monitoring and managing soil quality in tea plantations is important for ensuring the safety of tea products. I don’t trust the Chinese plantions to care about the soil quality.

WOW, that makes me want to scream.

I remember decades ago, a 60 minutes segment (maybe it was 20/20) reported how many of the pharmaceuticals sold in the US pharmacies are fake, and how they were so good the pharmacists could not even tell the difference. They somehow would get into the supply chain of the distributors.

They showed how dirty the ‘labs’ were (not resembling any sort of lab) and what stuck with me is they said the colorings were often road paint.

It made me afraid of anything from china … fast forward, it was only this year I learned that they actually do a good job with making APIs for our medicines and that most are made there.

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I remember being alarmed by that or a similar case. Then I found out later about this:

Authorities in New York have accused major retailers of selling herbal supplements that do not contain the listed ingredients. But now some scientists are questioning those conclusions, saying that the methods the authorities used to test the supplements may have yielded inaccurate results.

“There are profound problems with the quality of supplements in the United States,” said Dr. Pieter Cohen, an assistant professor of medicine at Harvard Medical School, who has conducted numerous studies on adulterated supplements. But Cohen said he found the results of the attorney general investigation hard to believe, because single-ingredient supplements — like the ones tested in the investigation — are much more likely to consistently contain the ingredient that matches what’s on the label. Cohen said he would have expected around 90 percent of store-brand herbal supplements tested from the stores to contain the labeled ingredient.

“If I had this kind of surprising, counterintuitive results, I would do additional tests,” said Cohen.

One problem with the investigation, Cohen said, is that the test officials used to analyze the supplements — called DNA barcoding — is not proven to work well in identifying whether a particular botanical ingredient is in a supplement or not.

That’s because looks for a specific fragment of DNA, but the ingredients in herbal supplements are often highly processed — crushed, dissolved, filtered and dried — so that they may no longer contain the particular fragment of DNA that researchers are searching for, making the supplement appear to be mislabeled, Cohen said. But the products could still contain some biological compounds from the original plant.

(One reason to doubt that things are as bad as was alleged is that if it were true, then it would mean that there are basically no safeguards in the U.S. whatsoever. While safeguards could be better, and are probably bad, they’re not non-existent.)

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