I am definitely going to take a large dose of sulforaphane 2 days before my next therapeutic plasma exchange.
I have been taking Dasatinib Quercetin the day before plasma exchange to purge the toxins liberated from senescent cells upon senolysis.
Imagine what is lurking inside senescent cells and is released into your system.
The problem is, the particles mobilized were >5 um in size, so those will lodge in capillary beds the very first time through circulation and yes, 20-25% of blood flow goes to the kidneys - but even then, itāll be the 5 um or smaller that get filtered, but these other particles, just like when they go to the muscles, the brain, etc, would get lodged in capillaries and potentially block blood flow, and presumably hopefully get re-phagocytozed into lysosomes. So the net benefit Iād predict would essentially be the risk of causing ischemia to areas seeing a whole bunch of moderate sized plastic particles, not small enough to get through the capillaries, but getting a whole bunch at once.
I might be wrong - but this would mechanistically be the thought process at least on my best understanding of how things work.
How are you measuring?
Which method / equipment?
I would just advise some caution on the dose. 10mg is used by many thousands of people every day, and has been shown to be safe. So you have nothing to lose by taking that before plasma exchange. My best guess is that that dose also mobilizes some microplastics.
Higher doses introduce more uncertainty and risk.
@DrFraser brings up some important concerns here. There are definitely more questions to answer before we can conclude that a large dose is of net benefit. We should have those answers soon.
I used this test after an overnight fast:
Since Iām using stabilized, purified sulforaphane, I donāt need the myrosinase enzyme to convert precursor glucoraphanin to sulforaphane.
With a precursor supplement that relies on this conversion (which is most of them), you canāt be certain exactly how much sulforaphane you are getting.
Brand / Supplier or Manufacturer?
Does it dump nanoplastics/shards or just plasticizers?
A quick AI searchā¦
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Stabilized Sulforaphane
Stabilized and purified sulforaphane refers to methods and formulations designed to enhance the stability and bioavailability of sulforaphane, a bioactive compound found in cruciferous vegetables such as broccoli. Sulforaphane is typically derived from its precursor, glucoraphanin, through the action of the enzyme myrosinase. However, pure sulforaphane is inherently unstable, which has led to the development of various stabilization techniques.2
One approach involves the use of cyclodextrins, which form complexes with sulforaphane to improve its stability. For example, a method of stabilizing sulforaphane includes contacting it with a cyclodextrin to form a complex between the two.3 This method has been patented and is part of the broader effort to develop stable forms of sulforaphane for clinical and nutritional use.4
In addition to cyclodextrin-based stabilization, other methods have been explored. For instance, the isolation and purification of sulforaphane from broccoli seed extracts have been the subject of several patents, including those held by Pharmagra Labs, Inc. These methods aim to produce high-purity sulforaphane while maintaining its biological activity.5
Research has also focused on the stability and bioavailability of stabilized sulforaphane preparations. Studies have shown that certain formulations, such as Ī±-cyclodextrin inclusion complexes, are as potent as pure sulforaphane in inducing cytoprotective responses in cultured cells, although they may differ in terms of bioavailability and side effects.6
Moreover, there are commercial products that claim to provide stabilized sulforaphane. For example, ProstaphaneĀ® is noted as a product that reliably contains stabilized sulforaphane, though it is primarily available in Europe.7 Other supplements, such as Crucera SGSĀ® (Thorne) and OncoplexĀ® (Xymogen), are also mentioned as potential sources of sulforaphane, though they may rely on the presence of both glucoraphanin and myrosinase to ensure optimal delivery.8
In summary, stabilized and purified sulforaphane involves various methods and formulations aimed at enhancing the stability and bioavailability of this compound, with ongoing research and development in this area.
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