Seems worthy of more testing.
If sulforaphane always results in such a sharp spike in blood microplastics then you could draw out blood or plasma and throw it away to remove it from the body.
It would be interesting to see the results after this is done multiple times. Is more of it in the blood or plasma?
Good for him! I’d certainly be doing it too, if I had millions of $ in spare cash.
Very cool. Plasma donation carries the benefit of removing things from the body and is free. Plasma exchange or filtration have their own benefits.
Bryan Johnson did state he didn’t really feel different after removing all of his blood plasma.
I could foresee a therapy where you dose super high levels of sulforaphane and filter or remove your plasma. Or maybe it requires full blood draw. Who knows? I’d want to see both tested. It would be good to see plasma filtration tested as well.
Sulforaphane is a natural plant compound (phytochemical) found in cruciferous vegetables. These vegetables include:
Just “Plasma exchange or filtration” may not remove plastic particles.
What size are the particles in the blood stream?
Review the following, posted as a separate thread.
So you’re saying the cheaper and more widely available plasma donation would probably be a better solution here?
But we don’t know that plasma removal would be effective, it might require discarding the blood all together.
If sulforaphane at high doses is really liberating microplastics into the blood this is worthy of a study determining different doses effects, and the benefit of blood and plasma removal.
I think the most accessible solution would be to donate plasma to a private company that is using the plasma to make fractionated drugs like IVIG or albumin. The processes used to make those generally include microfiltration steps that would remove microplastics, so you wouldn’t have to worry about contaminating the recipient patient.
A typical donation removes about 25% of your plasma, and thus an equal percentage of mobilized plastics.
I’m going to test this.
Please keep us updated. This is a huge discovery if it works.
I should also add that I was originally going to test this with rapamycin, but then the sulforaphane for NPC disease paper crossed my desk. Both of these drugs induce lysosomal exocytosis through TFEB. NPC also does it through a second mechanism (MCOLN1 activation).
I have a laundry list of things I need to test as follow ups, including whether rapamycin can also mobilize microplastics. If anyone reading this is about to start a round of rapa anyways, I would encourage you to measure your microplastic blood levels daily starting 1 day before and for 3 days after starting rapa. If you do, please share your results!
True but 55% of “blood” is plasma. 40% is red blood cells.
Since red blood cells have a very short lifespan of about 120 days, and they then get engulfed by macrophages. It is probably not a bad idea to do plasma “cleaning” or exchange after a sulphoraphane mobilization protocol.
Plasma is the food truck and the garbage truck, carries nutrients to where they are needed and carries waste away to be disposed of by the kidneys.
I’ve been wondering about a pseudo-osmotic potential. High concentration moving to a low concentration. If that may also apply to microplastics. Probably not but a lingering question in my little mind.
There are four basic processes in the formation of urine starting with plasma.
Filtration
Filtration is the mass movement of water and solutes from plasma to the renal tubule that occurs in the renal corpuscle. About 20% of the plasma volume passing through the glomerulus at any given time is filtered. This means that about 180 liters of fluid are filtered by the kidneys every day. Thus, the entire plasma volume (about 3 liters) is filtered 60 times a day! Filtration is primarily driven by hydraulic pressure (blood pressure) in the capillaries of the glomerulus.
Note that the kidneys filter much more fluid than the amount of urine that is actually excreted (about 1.5 liters per day). This is essential for the kidneys to rapidly remove waste and toxins from the plasma efficiently.
Thanks for sharing. I’m super fan of this molecule, so many studies and good results.
I wonder now which other molecule could be added to sulforaphane that can help to lead the toxin off the body… Sulforaphane per se for detox worries me a bit as it can cross the BBB.
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In another note, have you added myrosinase to the sulforaphane formulation? Just curiosity as some studies say it helps conversion from glucoraphanin to sulforaphane (bioavailability). (Maybe vitamin C as well as a cofactor for myrosinase and for some antioxidant help.)
I am definitely going to take a large dose of sulforaphane 2 days before my next therapeutic plasma exchange.
I have been taking Dasatinib Quercetin the day before plasma exchange to purge the toxins liberated from senescent cells upon senolysis.
Imagine what is lurking inside senescent cells and is released into your system.
The problem is, the particles mobilized were >5 um in size, so those will lodge in capillary beds the very first time through circulation and yes, 20-25% of blood flow goes to the kidneys - but even then, it’ll be the 5 um or smaller that get filtered, but these other particles, just like when they go to the muscles, the brain, etc, would get lodged in capillaries and potentially block blood flow, and presumably hopefully get re-phagocytozed into lysosomes. So the net benefit I’d predict would essentially be the risk of causing ischemia to areas seeing a whole bunch of moderate sized plastic particles, not small enough to get through the capillaries, but getting a whole bunch at once.
I might be wrong - but this would mechanistically be the thought process at least on my best understanding of how things work.
How are you measuring?
Which method / equipment?
I would just advise some caution on the dose. 10mg is used by many thousands of people every day, and has been shown to be safe. So you have nothing to lose by taking that before plasma exchange. My best guess is that that dose also mobilizes some microplastics.
Higher doses introduce more uncertainty and risk.
@DrFraser brings up some important concerns here. There are definitely more questions to answer before we can conclude that a large dose is of net benefit. We should have those answers soon.
I used this test after an overnight fast:
Since I’m using stabilized, purified sulforaphane, I don’t need the myrosinase enzyme to convert precursor glucoraphanin to sulforaphane.
With a precursor supplement that relies on this conversion (which is most of them), you can’t be certain exactly how much sulforaphane you are getting.