Wow! I had been using the best AI models from OpenAI once every 4 to 6 months to see where it was. I was spending $200 a month to test it. I had no plan, you have opened my eyes to what is possible. You have given me a plan, a strategy, and am making progress.
Thank you for posting this level of detail, especially the picture of your spreadsheet. I did not start out with a spreadsheet, but I can see that makes sense because it is in smaller bite sized (TABS) of data to be written or accessed.
I made a lot of headway by starting, which is 90% of the battle. Need to collect more raw data on myself and that will happen over the next year.
Baby steps. Read and follow the details laid out in your posts.
FWIW:
I can only offer anecdotal evidence for some things that are somewhat supported in humans and for others that are supported in animal studies but not in humans. I am 85 years old, and my current health suggests I will live at least another 10 years. The list of life extension drugs that I use after much research.
Of course, rapamycin is number one on my list. I have been taking it for five years, once weekly, at fairly high doses. Before taking rapamycin, I was using a cane to walk and had what I assume was arthritic pain in my joints. I also had chronic actinic keratosis from excessive sun exposure when I was young. Rapamycin gave me pain relief in a short time, a month or so, and stopped the actinic keratosis. I now walk without a cane, and I only see a dermatologist every two years; in fact, I actually haven’t seen one in three years. If you read the threads, you will find a wide range of rapamycin dosing protocols. I have chosen to use the protocol suggested by “Dr. Mikhail ‘Misha’ Blagosklonny (1960–October 2024), who was a brilliant and visionary physician-scientist, professor of oncology, and theoretical biologist who made paradigm-shifting contributions to cancer research and the field of geroscience.”
Basically, the dose is the highest without unwanted side effects. I have experimented with various doses over the last five years. My maintenance dose of rapamycin is 8 mg weekly with GFJ. Blagosklonny: “The higher the dose, the higher the anti-aging benefits.”
Note: I take Imeglimin instead of metformin because I can’t tolerate metformin. I believe metformin is the better choice for most.
Of course, I take many other supplements, but I believe they are mostly for healthspan. And my own observations of many older people I have known show that exercise and diet mostly extend healthspan.
Of course, one could argue that healthspan extends lifespan.
I am going to try to follow Beth and create an aging research AI system using Claude. I have just started and I think this is the way to go. I can work on it for years and as AI becomes more powerful, the AI’s ability to help me live longer will be better.
I will research everything, all known and emerging longevity drugs.
I use Dr Bradley Rosen https://mtormd.com/
Been with him for over 3 years. Common sense and focus on the basics. Very reasonably priced, no subscription, charges per consult and gives you well over an hour of time! Solid MD background, based in LA. Real value for your money with medical advice that is very solid and not bought by supplement and peptide companies.
I like the guy. I really appreciated the lack of hyperbole in his descriptions and his frank admission that we have little data on humans in most areas.
I agree with your med list with 1 addition- an SGLT2i . I recommend Brenzavvy because I can get it from Mark Cuban. And if you are recommending you should give dosages and regimen (Rapamycin 8mg weekly for me?
Lab order for Cleerly CCTA for an investigation into my plaque.
Acarbose 100mg tab, when needed
Tirzapatide and schedule
Zetia (ezetimbe) 10mg daily
Sirolimus, 6mg weekly
and more
I will ask them about all other compounds mentioned withtin this thread in the coming weeks. They are very progressive, and I am willing to try everything that I can afford if it seems likely to lenghten my life.
I would suggest the introducing of new substances to your body at will it is not a very good idea. I think it is more of a measure twice (well make that measure 10 times) and cut once. I get the impression that you are of the belief that you really need to do something/everything and very fast or else you’ll drop dead tomorrow or at 76 (average for a man in US). First, no one knows how long you, I or any one of us will live despite what we are taking. Second there is zero proof that what we are taking will add one extra second to our longevity (though it is every one’s wish that it will add some) so just take a deep breath, take it easy, take it slow, and start with all the medicines at VERY low doses. I.E you’d have to be nuts to do 6mgs of RAPA the very first time you ever tried it. So be careful bud because I get the impression that you are rushing into this and before you know it you might end up hurting yourself. Just my two cents.
I am a 66 year old male, 5’-8", weigh 217lbs. I yoyo with my weight between 190 and 220lbs. I have been on the forum for ~3.5 years. I am not here every day, but I am here quite often. Although I may not log in for a month or two, I am still reading about longevity and what is happening in longevity on Twitter/X.
Like everyone, I am not the specimin of health that I was when I was 20. But was I ever a specimin of health? NO. I used to work in construction 40 to 60hrs a week, 7 days a week for 365 days per year, and was one heck of an athlete, yet at 26 when I tried to join the US Marine Corps, I was denied due to a bicuspid aortic valve. I had that replaced in 2017.
I am doing quite a bit to catch cancer and cardiovascular issues early. I will spend $20,000+ preventively this year to try and make sure my health is as good asI can get it.
I bought rapa and acarbose once before and did not take it because I was taking care of my mother in hospice and did not think it was wise at the time to get side-tracked. I had a lot on my plate.
I will do as you say, be wise, and take 2mg the first few weeks to see how things go and ease into the full 6mg, if I ever take the full 6mg.
I could be dead 30 seconds from now. Trying to avoid it. 4 people have died right within arms length of me so far. I know death and want to live.
This is truly fasinating, Beth!
I heavilynuse Claude for work, financial planning etc
For health, not to this extent(embarassingly)!
May be I was just waiting for someone like you to invent the wheel so I dont have to reinvent. Which is exaxtly what I intent to do.
Thank you for sharing in such a great detail!
You shared a key piece of information here - the fact that you’ve had a bicuspid aortic valve replaced. The surgery here is absolutely life saving and I’m glad they were able to diagnose and replace it. Did you get a mechanical valve or a tissue valve?
This is likely to be your biggest bottleneck in making it to an old-age and needs to be focused on with great detail. Rapamycin could theoretically be risky as it MAY increase the risk of endocarditis, so you should be very careful. Additionally, if you take anti-coagulants like coumadin/warfarin, you’ll need to be very cautious about maintaining a stable INR. While the drug is essential and life-saving, it interacts with almost everything under the sun and send your INR all over the place.
If you have a biological valve (likely sparing you the need for blood thinners) and need open-heart surgery in 10-15 years, you’ll have to consider the impact that will have on your body. Procedures like that are about as major as it gets in terms of their impact on the body.
Regardless of what you decide, please consider keeping the people of this forum posted to share your experience.
I had a tissue valve and 3-way bypass performed with open heart surgery in 2017. I would only need open heart surgery if I need additional bypass surgery and they decided against stents. Stents and valves can be inserted via leg vein.
I am not taking any prescribed blood thinners.
On 09/18 I have a Zoom call for one hour with Prenuvo to review my Executive full body MRI and 80 blood biomarker test.
The thing that drew me to this clinic was that they were willing to discuss a prescription/order for a Cleerly CCTA heart scan of hard and soft plaque. I take the Cleerly on 09/22.
I have doctors at Foster Medical Clinic, KY, USA that I just joined, a KY state hospital and the Cleveland Clinic. Everyone is working to get me as healthy as I possibly can be.
I have taken the GRAIL Galleri test twice and am waiting for the reults on the 2nd test.
I signed up for the CancerGuard test and am waiting for my blood draw.
I take the PSA test regularly, and will soon schedule for a blood based Alzheimer’s Test, and second colonoscopy.
I feel like I am in good hands. Every test so far has come back good.
Beth, from all the work Claude has spent researching, are there any documents you’d be open to sharing? Setting up something similar myself right now where it’s scouring research papers etc. and this could be very time saving if you’ve already had yours do a lot of leg work!
