What would the human dose equivalent be of 0.86mk/kg per day? Forgive my inability to know how to convert rat doses.
Perplexity tells me about 5 mg/day: https://www.perplexity.ai/search/what-is-the-human-dose-equival-l6.d9zFKTYOWjtnS01_IaQ#0
Which is a lot. That’s the Parkinson’s dose. And there’s zero evidence that Parkinson’s patients on selegiline live longer or have any improvements other than symptomatic. People who use selegiline for “longevity” take about 1 mg/day (or 5 mg/week by cutting the 5 mg pill in four to use 1.25 mg/day, 4 days per week).
I wrote this article on Selegiline: Selegiline - Longevity Wiki
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Great article. I occasionally check out Longevity Wiki and didn’t realize you wrote for it.
I agree that 5mg daily seems to be high for longevity. I have been taking 1.25mg per day on and off for around 7 years maybe, ever since I read about it in Life Extension magazine. I’m very interested in what more research ends up telling us here.
I only wrote that article, any one can write anything btw. And it seems that the project is dead.
Anyway, after writing this article I became less convinced about selegiline. Hopefully I’m wrong. Time will tell. I’ll wait to see the ITP results (or anything else convincing) before trying it…
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I have to say it doesn’t look too compelling to me after reading it either. Might have a small benefit but I don’t think it will be anywhere close to Rapamycin or Acarbose level.
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Yes, its rare that you see old research dusted off and restarted… seems worthwhile given what we know: Deprenyl - Anti-Aging Drug Proven Effective in Dogs
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Stoked to see glynac especially since they’ve already done glycine alone
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I have a feeling we are going to see a really good result here, as long as they use a high enough dose.
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I hope they are measuring such that we can rule out my hypothesis that the effect is just from NAC making the food taste bad resulting in caloric restriction
This 1997 study is probably the strongest evidence
Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice - PubMed (nih.gov)
I have a feeling that we will see similar results to what we saw with astaxanthin, i.e. male median lifespan +12%, male maximum lifespan +6% (not statisticaly significant).
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I would like to test Harmine and GLP-1 as antagonists for increased insulin production/ potentially increased Beta Cell regeneration. There was a comment above that the ITP does not test injectables. Rybelsus is a semaglutide in pill form – perhaps that can be used?
Would also like to test Berberine.
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Oral semaglutide has a super low absorption, that’s why it’s not tested. We need better oral GLP-1RAs and the ITP will test them.
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Agree we need better oral GLP meds. But to compensate for the poor absorption, Rybelsus pills are dosed far higher than injectables, with the 7 and 14 mg pills supposedly comparable to the two most often prescribed doses of the injectable semaglutide.
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I know but I think they’re afraid mice could not eat all of that.
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How about mifepristone? This study showed lifespan extension in fruit flies - and combining with rapamycin, the combination didn’t do better, implying some overlap in their mechanism of action. It’s the drug used for early-stage abortions (combined with another drug), so with the new administration in Washington DC, I wonder if access to the drug might be restricted.
In regard to it being restricted, this is a state issue, not a federal issue. In my state of TN, everything is extremely restricted. Edited per @ng0rge 's wise advice!
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Careful…that’s a banned word and so are the “other guys”. I think you can still say “Washington, DC”, but we’ll see how @RapAdmin feels tomorrow.
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A new study https://x.com/mike_lustgarten/status/1971727282600288615
IL-6 inhibitor shows promising in longevity but it is impossibly hard for the average joe and so expensive. What about a pulsed Predinison 5mg every 10 days? I looked up IL-6 alternatives, and Prednisone seems to be one of them.
I know, literally every doctor I know thinks Prednisone is evil. However, my mom has been on it for many years, and she has done alright for some reason (as measured by bone density and other systems). I should add, though, that she was on Fosamax.
Also, what about pulsing of methotrexate?
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I am not a doctor, but it mimics cortisol and puts your body into a very stressed state; higher heart rate, water retention, raises your fasting glucose, muscle loss, fat gain (including fat formation inside organs), etc. None of that sounds good for longevity.
But I do agree that the concept of less frequent dosing is very interesting. My wife has some autoimmune tendencies, and presnisolone has been a hell of a powerful tool in the arsenal when needed. It’s very very effective at squashing excess inflammation.
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