Study of Japanese Centenarians Identifies a “Unique” Gut Microbiome


Paper (paywalled)

Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

Distinct gut microbiome ecology may be implicated in the prevention of aging-related diseases as it influences systemic immune function and resistance to infections. Yet, the viral component of the microbiome throughout different stages in life remains unexplored. Here we present a characterization of the centenarian gut virome using previously published metagenomes from 195 individuals from Japan and Sardinia. Compared with gut viromes of younger adults (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previously undescribed viral genera, such as viruses associated with Clostridia. A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and bacterial members of the centenarian microbiome displayed an increased potential for converting methionine to homocysteine, sulfate to sulfide and taurine to sulfide. A greater metabolic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and resistance to pathobionts.


It must be the Nattō


Eat “Nattõ”

Cheap Insurance.

And you are going to like it.

No, you are going to get use to it.

I’ve eaten it a few times. The one time I almost liked it was at a restaurant in Japan that specialized in it. I suspect that places that don’t specialize / serve it in volume are probably not the best place to try it.

In general I like fermented things, but Natto is tough to enjoy.

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