Study identifies factor in 'young blood' that helps rejuvenate aged mouse muscle

The study demonstrates that circulating shuttles called extracellular vesicles, or EVs, deliver genetic instructions for the longevity protein known as Klotho to muscle cells. Loss of muscle function and impaired muscle repair in old mice may be driven by aged EVs, which carry fewer copies of these instructions than those in young animals.

Research Paper:


This report and the one below are more good news for rapamycin promoting muscle youthfulness
Exosome Release Is [Negatively] Regulated by mTORC1

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This is an interesting study in some ways. One thing that is not clear is what tissue is the primary source of the extracellular vesicles? I don’t have access to the paper at the moment, so if anyone who has read the paper can chime in and maybe fill in that information it would be appreciated. I wonder if these extracellular vesicles are functioning in an “endocrine” manner as opposed to say something local to the (youthful) muscle tissue.


Aaron, Thanks for posting and welcome to the site. You have some good questions - but it is hard to get a hold of the full paper.

With not updating their database right now due to the India Lawsuit, all we can get are papers prior to 2021 - so unfortunately we’ll have to wait to read the full paper.