Perhaps everyone suspects this already, but good to see the scientific validation. One thing I’d like to learn more about is how stress (i.e. raised levels of cortisol and glucocorticoids) impacts MTOR. It seems to have some effect at blocking mTOR but I’ve just started researching this: Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History | Endocrinology | Oxford Academic and Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head - PMC
From a practical standpoint I’m wondering if taking rapamycin during times of high personal stress is a positive approach or negative as you are already shutting down mTOR due to the cortisol, etc?
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.
Open Access Paper: