NSAIDs are contra indicative for heart disease.
NSAIDs: Do they increase my risk of heart attack and stroke? - Mayo Clinic.
If you are at risk for colon cancer, like it appears I am, you should have regular colonoscopies to remove polyps. If you have one and youāre all clean, your doctor should provide you with a timeline as to if/when you should check again. I hope that people here donāt have cancer or polyps so they can avoid regular colonoscopies.
For me, I need one every 3.5 years. Thatās just the way it rolls. Iād rather have a polyp removed instead of finding a malignant tumor a few years later. Iād recommend everyone to have at least one to find out if they are at risk or not. Or at least talk with your doctor about it.
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Right. Since Iāve had 3 clean colonoscopies over the last 15 years they now tell me to get one every 10 years. Iāve got other problems to make up for this one.
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From the article you cite: āNSAIDs: Do they increase my risk of heart attack and stroke?ā " Aspirin doesnāt appear to be associated with a higher risk of heart attack or stroke"
As for other NSAIDs, they do not all have equal risk.
From the literature I have read, Naproxin has the lowest risk.
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Can aspirin help protect against colorectal cancers?
A new study details how a daily dose could prevent or delay the progression of the worldās third most common type of cancer.
Now a new study published in the journal Cancer shows that colorectal cancer patients who took a daily dose of aspirin had a lower rate of metastasis to the lymph nodes and stronger immune response to their tumors. The research suggests that aspirin may be boosting the ability of the immune system to hunt for cancer cells.
āIt is a rather unexpected effect, because aspirin is mainly used as an anti-inflammatory drug,ā says Marco Scarpa, a researcher at the University of Padova, and one of the authors of the study. As Scarpa notes, this study suggests that aspirin may be playing a slightly different role by stimulating the immune systemās surveillance response, which can then prevent or delay the progression of colorectal cancer.
In a 2020 meta-analysis, which analyzed the results of 45 observational studies, researchers found that regular aspirin use was associated with less incidence of colorectal cancer.
A low dose, between 75 and 100 milligrams, was associated with a 10 percent reduction in the risk of developing colorectal cancer; a regular dose of 325 milligrams was associated with a 35 percent decline.
Other studies have shown a link between daily aspirin and a delayed progression, including a lower risk of dying in patients who had already been diagnosed with colorectal cancer.
https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.35297
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A few other stories on the Aspirin study for colon cancer:
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SGLT2 inhibitors reduced the risk for colorectal cancer by 39%
Colorectal cancer upregulates the expression of sodium-glucose cotransporter 2 (SGLT2)
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New magic pills. We get some every 20 years or so.
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@adssx have you seems more broadly across your lit review of flozins?
How much do people think this effect carries over to fully healthy people?
I didnāt dig into SGLT2i and cancer much but whenever I found something interesting, I posted it here: Search results for 'cancer topic:91 @adssx order:latest' - Rapamycin Longevity News
Some studies are quite impressive indeed, but yes, mostly done in diabetic people. Would be good to do similar studies in non-diabetic people with CKD or HF (unless people with CKD or HF but without T2D have a higher risk of cancer?).
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Even more results on lung cancer
Results: SGLT2 inhibitor use was associated with significantly reduced mortality risk after adjusting for potential confounders (HR = 0.68, 95% CI = 0.60-0.77) with stronger association for longer duration of use (HR = 0.54, 85% CI = 0.44-0.68). Further, we found that SGLT2 inhibitor use was associated with a significant reduced risk of mortality regardless of patientsā demographic, tumour characteristics and cancer treatments.
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To screen for colon and rectal cancers, most people have colonoscopies, which can feel invasive and require anesthesia, or they may take an at-home stool test, which can be more convenient but also awkward - and not appealing for the squeamish.
But a simple blood test could soon become more broadly available.
Palo Alto, California-based biotechnology company Guardant Health has applied for US Food and Drug Administration approval of Shield, its blood test to screen for early signs of colorectal cancer, and a panel of expert advisers to the FDA is set to evaluate data on the screening test this week.
The company behind the test:
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Just got the pathology report back from my colonoscopy. Instead of 2 polyps, there were 3.
In my most recent colonoscopy at the beginning of last month, the doctor found 3 tubular adenomas which each had a 10% chance of becoming cancerous. Iām glad theyāve been removed.
A 30% chance of having cancer within 5 years is not a good bet. Itās easier removing a polyp than cancer.
Next colonoscopy in 3 years.
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Younger Adults Are Missing Early Warning Signs of Colon Cancer
May 24, 2024
Colorectal cancer rates are rapidly rising among adults in their 20s, 30s and 40s, and the most common warning sign for the disease is passing blood in the stool, according to a new scientific review.
Rectal bleeding is associated with a fivefold increased risk of colorectal cancer, according to the new analysis, which looked at 81 studies that included nearly 25 million adults under 50 from around the world.
Abdominal pain, changes in bowel habits and anemia are other common warning signs of the disease and should not be ignored, said the researchers, who published the paper on Thursday in the journal JAMA Network Open.
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Btw are you taking SGLT2i?
Yup, 6.25mg empagliflozin daily but considering upping it to 25mg a day for weight loss. With my new salary I think I can afford the full dose 
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Is this equivalent to a 25 mg tablet split into quarters? Iāve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control. But I still need to take the plunge. How long have you been taking it? Can you share any pros and cons? the unpredictability of caloric output can be frustratingā¦ #controlfreak 
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Correct.
Iāve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control.
Most of the benefit is seen at the 10mg dose already though the 25mg dose seems to cause increased weight loss so that what Iām considering.
How long have you been taking it?
2 months now.
Can you share any pros and cons?
Pros: I donāt seem to put on much weight anymore despite eating like a pig on weekends.
Contras: at higher doses I crave sugar.
Overall, if it wasnāt for the price, a great drug for kidney protection and weight control. I prefer it over acarbose.
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Ohio State University (OSU) researchers have a chilling theory as to why colorectal cancer is rising in young adults, hypothesizing that a popular diet may be to blame. The findings were presented last week during the American Society of Clinical Oncologyās annual conference in Chicago.
The OSU researchers are sounding the alarm about diets which are high in fat and low in fiber. Specifically, scientists believe the āWestern dietā can unsettle the particular balance of bacteria within your gastrointestinal tract. This can cause inflammation which ages cells at an accelerated rate, making them more susceptible to cancer.
The results of the study found that young people who develop colorectal cancer are, on average, biologically 15 years older than their chronological age.
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The high bio-available Curcumin knocked my platelets to below the lower level of the blood test range. It took some figuring but I narrowed it down to the Curcumin I was taking. I stopped the supplement and my platelet level moved back up. Something to be cognizant of. Cheers
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