Professor Lloyd Trotman’s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression in mice. The supplement is a precursor to vitamin K, commonly found in leafy greens.
It is enough to eat K1 or do we need menadione itself or do we get it from leafy greens intake? Seems like K2 was not involved here right
Research from Flinders University and Medical Research Institute in Australia, published in the European Journal of Nutrition, builds upon existing evidence uncovered by the same team, which shows that a diet high in fruits, vegetables, whole grains, fish, legumes and dairy may help protect against gastrointestinal cancers.
Researchers have found strong connections between poor diet and a higher risk of digestive cancers.
They suggest that eating more healthy fats and vegetables, while cutting down on sugar and alcohol, can greatly lower the risk of colorectal and other types of cancer.
A new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine reveals that biological age—reflecting the cumulative impact of genetics, lifestyle, and environment—may predict the risk of developing early colorectal cancer. Published in Cancer Prevention Research , the findings highlight accelerated aging as a key risk factor for colon polyps, a precursor to colorectal cancer, and suggest targeted early screening for those aging faster than their chronological age.
This is a BS press release. The investigators have no data on the subjects’ diet: all they have is tumor samples, which show an abnormal pattern of eicosanoids. By the time you already have cancer, whatever drove you to cancer may be long gone. There is every reason to think that that the abnormal eicosanoids are the result of mutations in the cancer, not Cheetos.
I’ll have to read the entire paper…
Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer . Gut , 2024; gutjnl-2024-332535 DOI: 10.1136/gutjnl-2024-332535
More good news for rapamycin users:
Two years ago, LUMC researchers discovered that infections with Salmonella can increase the risk of colon cancer. New research sheds light on how this bacterium, which sickens millions of people every year, can cause this. The findings provide new leads for new treatments.
How can salmonella infection lead to colon cancer?
It all revolves around a protein complex located in our cells called mTOR. This protein helps the cell decide what to do based on available energy and nutrients. You can think of mTOR as the central regulator in the cell. The protein ensures that metabolism (the process by which a cell converts substances into energy) and cell growth and division occur in a controlled manner.
The researchers found that when Salmonella infects a cell, the bacteria use nutrients from that cell to multiply. This disrupts the normal balance present in the cell, and mTOR becomes severely dysregulated. As a result, the cell becomes cancerous: the cell grows faster and begins to divide uncontrollably. “What is striking is that even when the bacteria are gone, the cell remains in a cancerous state. This increases the chances of forming tumors,” says Dr. Virginie Stévenin, who coordinated the study together with Prof. Dr. Jacques Neefjes.
Reversing damage caused by salmonella infection
The good news is that the scientists may also have found a solution to this problem. "We discovered a way to influence the multistep process of cancer formation with a previously discovered inhibitor, a substance (inhibitor) that can temporarily block the action of mTOR. After a while, we saw that this caused the cells to return to their normal state. Our laboratory research suggests that there is a way to reverse the harmful effects of Salmonella infection", Stévenin (photo) explains.
Even though she adds: “These findings remain to be tested in complex pre-clinical models to see if the inhibitor will also work on more advance stage of tumor formation. As such mTOR inhibitors are already used in clinical trials for cancer treatment, they could be used in the future as most effective treatment for colon cancer induced by Salmonella infection, and maybe from other bacteria as well.”
Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonellainduces cell transformation, we performed multi-omics and phenotypic analyses of Salmonella clinical strains isolated from patients later diagnosed with colon cancer (case strains) and control strains from patients without cancer. We show that high transformation efficiency is a frequent intrinsic feature of clinical (case and control) salmonellae, yet case strains showed higher transformation efficiency than control strains. Transformation efficiency correlates with gene expression, nutrient utilization, and intracellular virulence, but not with genetic features, suggesting a phenotypic convergence of Salmonella strains resulting in cell transformation. We show that both bacterial entry and intracellular replication are required for host cell transformation and are associated with hyperactivation of the mTOR pathway. Strikingly, transiently inactivating mTOR through chemical inhibition reverses the transformation phenotype instigated by Salmonella infection. This suggests that targeting the mTOR pathway could prevent the development of Salmonella-induced tumors.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01282-8
Didn’t know if this had already been discussed:
Might be worth considering for those taking antibiotics as longevity supplements.
Interesting, found this also from the Colon Cancer Foundation;
Among all of the individuals who were accounted for during the approximate 18.2 years, 422,778 were diagnosed with cancer. While low-dose aspirin usage during a short period of time (<5 years) did not show statistical significance in preventing cancer, long-term use (5+ or 10+ years) was associated with at least a 10% reductions in risk for several cancer sites throughout the body (including the colon, rectum, esophagus, stomach, liver, pancreas, etc.). Additionally, high-dose usage was associated with an even higher percentage of risk reductions for developing these cancers.
Overall, this study found that individuals who took aspirin had less spread of cancer to their lymph nodes as compared to those who did not take aspirin. The study also found an association between aspirin usage and a reduction in the risk of CRC.
I won’t argue against aspirin use, but people underestimate the risk, especially in older people where the risk of a brain bleed after a fall is 40% higher if taking aspirin.
Your post is confirmed below:
When you have blood in your stool, it can look a few different ways. You may have bright red streaks of blood on your poop, or you might see blood clots or blood and mucus mixed in with it. Your stool could also look dark, black and tarry. The color of the blood you see may be a clue to where it’s coming from:
Bright red blood in your stool usually means the bleeding is lower in your colon, rectum or anus.
Dark red or maroon blood can mean that you have bleeding higher up in your colon or your small intestine.
Melena (black stool) often points to bleeding in your stomach, such as a bleeding stomach ulcer.
Sometimes, rectal bleeding isn’t visible to the naked eye and can only be seen through a microscope. This is called occult bleeding. You may discover this type of blood in your stool if you have a lab test done on a stool sample called a fecal occult blood test. It’s a screening test for colorectal cancer.
Dietary prevention:
https://www.ergo-log.com/every-10-g-carrot-reduces-chance-of-prostate-cancer-by-5-percent.html
It is an associational study, like most food studies are. It is a Chinese meta study.
The Chinese publication is a meta-study: the researchers used 10 previously published epidemiological studies for it. They found no indications of bias, which means that it was not only positive or only negative studies that had been published.
The Austrians posit another basis for the protection, apart from the usual suspects - carotenoids…
https://www.ergo-log.com/polyacetylenes-cancer-inhibitors-in-carrot-celery-parsnip.html
Their table shows the highest concentrations of falcarinol and falcarindiol actually come from parsnips, with celery a close second.
Aspirin inhibits cyclooxygenase which creates prostaglandins. In other topics there are disscussions as to the benefits of prostaglandins.