I wonder what you make of the above video by Nick Norwitz?
Based on the study last year on PCSK9 inhibitors being successful for primary preventions, my belief has been that all the ApoB-lowering medications can be preventative but of course some are better than others when it comes to side-effects
https://www.eurekalert.org/news-releases/1105011
https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
Feels like an important detail to not leave out:
A key message of this work is to distinguish between the practical implications of individual surrogacy and trial-level surrogacy. Overall, evidence demonstrates the individual-level surrogacy of LDL - c and non-HDL-c, i.e. their prognostic value on the occurrence of cardiovascular events.7–9 As such, they are relevant biomarkers for the follow-up of patients treated with statins. This is why the recent NICE guideline on cardiovascular risk management now recommends a 40% reduction in non-HDL-c after 3 months of high-intensity statin treatment.12
Based on watching the video sounds like he’s arguing for the opposite conclusion.