Statin usage and Desmosterol

#81

Just an update in case there are folks following this thread/in a similar position to me.

As you’ll recall, rosuvastatin brought down my ApoB score but caused low desmosterol (<.8) so I stopped (I’m APOE 3/4). Switched to praluent, which didn’t bring down ApoB sufficiently so I added ezetimibe 10mg, which in combination with praluent brought ApoB down to 57. Since it has been several months, I decided to retest desmosterol from Boston Heart and things look better. Desmosterol at .9 and ApoB holding steady at 56. Now I’m going to add indian bempedoic acid into the mix to see if that will drive down ApoB even a little lower without negatively affecting desmosterol.

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#82

Related, I’d still like my desmosterol to be a bit higher given the APOE4 gene. Anybody know how to raise it?

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#83

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13543
Statins were associated with better (less demented) d-scores in ε4 carriers but had no effect in non-ε4 carriers.

This answers your question if statin effects are only on the non apoe4 outweighing harms to carriers.

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