As a result of some research I have done on the Internet, I have come up with a rather speculative idea about how headaches might be cured. I don’t know if anyone else has thought about it or if it will work.
I have discovered that headaches are caused by too much vasodilatation and that adenosine causes vasodilatation.
I have also discovered that caffeine blocks adenosine receptors in your brain and that your brain cells compensate for this by growing more adenosine receptors. This means that when the caffeine has left your system, your brain is now more sensitive to adenosine which means you are now more prone to headaches.
I therefore suspect that people who are more prone to headaches than others may be people who naturally have more adenosine receptors in their brains. What do you think?
My idea is therefore to considerably reduce the number of adenosine receptors in the brain.
Does anyone here know of any drugs or treatments which can do this? I have not been able to find such a drug or treatment.
“The once-popular vascular theory of migraine, which suggested that migraine headache was caused by the dilatation of blood vessels while the aura of migraine resulted from vasoconstriction, is no longer considered viable”
Vascular as the cause is likely wrong, but Vascular changes do occur. Cause vs effect.
According to the older vascular theory of migraine, headache is produced by vasodilation and aura by vasoconstriction, but this theory is no longer viable.[23] Nowadays, the suggestions pose that multiple primary neuronal impairments lead to a series of intracranial and extracranial changes that cause migraines.
Still I take propranolol that is really good at alleviating my headaches. Maybe there is another pathway how propranolol affects headaches but in my case it is as effective as strong pain medications, I just have to take as soon as I sense headache developing.