Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations

Overall, with a few exceptions like cancer, results from recent DNA sequencing studies do not add weight to the idea that somatic mutations with age drive ageing phenotypes and the phenotypic role, if any, of somatic mutations in ageing remains unclear.

A paper which I agree with. I think somatic mutations matter, but the phenotypes are driven by problems with transcription and translation.