Just an anecdote, but I started collagen hoping it would help my hair and skin. It hasn’t at all. But my knees have never felt better! Joint pain has vanished, even the day after leg day.
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Very convincing that standard collagen peptides aren’t useful for joints, but he barely talks about the skin studies. Either way, it sounds like industry-sponsorship of studies is a major problem:
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He makes a lot of good points about the confounders for increased collagen synthesis in joints and the mechanistic rationale makes sense - tl;dr vitamin C is likely the main driver along with sufficient protein intake. With that said, if I were having surgery where post-op I want increased collagen synthesis, I would follow the protocol in the RCT since it’s the best and only evidence we have for improved collagen synthesis in joints.
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New video from Stanfield about the subject. Very good breakdown.
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Shitposting here wouldn’t be as fun if it didn’t cause a blip on the radar for longevity influencers a few days later.
So the protein equated RCT for skin health was only for treating burns and we don’t know how generalizable that is to other skin health.
Brad did well with the criticism of meta-analytic reviews, that was simple and to the point.
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