Ever looked into SR9009 or SR9011? They’re implicated in circadian clock modulation. It might be of interest to you.
I just posted a deep dive on the studies on both of these: Anyone Tried Various Modulators of Circadian Systems? - #3 by AustraliaLongevity
GPT analysis on the potential longevity implications of doubling REM sleep without increasing sleep duration:
What REM amplification drugs like BMB-101 could mean for longevity
• Sleep becomes an active rejuvenation platform, not just recovery
Doubling REM without increasing sleep time means the brain gets far more neural repair, emotional detoxification, and synaptic optimization every night. This turns sleep into a nightly cognitive rejuvenation cycle rather than just downtime.
• Chronic stress and inflammation would be structurally reduced
REM sleep is where the brain shuts off norepinephrine and processes emotional memory. More REM means less baseline stress signaling, lower cortisol, and less systemic inflammation, all of which are core drivers of aging.
• Neurodegeneration risk would likely drop
REM supports synaptic pruning, network reorganization, and metabolic waste clearance in the brain. Enhancing it could slow or prevent processes involved in Alzheimer’s, Parkinson’s, and age related cognitive decline.
• Mental health and biological aging are tightly linked
Depression, anxiety, PTSD, and burnout all suppress REM and accelerate aging. By restoring REM, you attack both psychological suffering and the biological wear and tear that comes with it.
• Learning, plasticity, and skill retention would stay youthful
REM is where new memories, motor skills, and abstract patterns are consolidated. Maintaining high REM across decades means preserving the brain’s ability to adapt, which is one of the strongest predictors of long term cognitive health.
• Sleep efficiency increases instead of sleep duration
Longevity is not just about sleeping more. It is about sleeping better. Converting light, low value sleep into high value REM is like upgrading the quality of nightly cellular maintenance without increasing time spent unconscious.
• This fits perfectly into a “Sleep 2.0” model
A drug like BMB-101 would be one component of a future system that combines pharmacology, wearables, environment control, and biological feedback to turn every night into a targeted rejuvenation session.
• This is the kind of intervention that compounds for decades
One good night helps. Ten thousand optimized nights could reshape aging trajectories. REM amplification is the rare lever that could quietly produce massive gains over a lifetime.
I can’t find any more announcements from this womans profile or the organization she works for but apparently the molecule they were working with was called Harmine.
- Sleep deprivation leads to alterations in mitochondrial health and a protein complex known as DREAM.
- Harmine, which blocks DREAM, mitigates the cellular aging triggered by sleep deprivation.
- Blocking DREAM allows cellular repair genes, such as antioxidant genes, to be activated.
What is harmine?
GPT analysis:
In the Context of Sleep and Aging
In the sleep deprivation study you referred to, harmine is being tested not for its traditional neuropharmacology but for its ability to block components of the DREAM complex, enabling repair gene activation in conditions where sleep is insufficient. That is a distinct molecular angle from its roles as a MAO-A or DYRK1A inhibitor and speaks to emerging research on cellular aging pathways.
Bottom line:
Harmine is a multifunctional natural alkaloid with a long traditional history, multiple molecular targets in the nervous system, and a emerging experimental role in cellular repair pathways. Early research suggests both potential benefits and dose-dependent risks, but it remains far from validated as a therapeutic in humans outside of tightly controlled studies.
To me this indicates harmine could be another worthy candidate for ITP testing, and certainly for improving sleep which I believe is one of the main levers we will end up using for meaningful lifespan extension.