I looked at this paper and saw this comment which I found interesting. Has anyone tried this:
Senolytics, such as dasatinib and fisetin, are drugs that selectively eliminate senescent cells and are already topically administered to the skin, showing potential antiaging effects.
I recently used a topical made of DMSO and a combination of dasatinib, fisetin, procyanidin, and quercetin. I don’t know if I can report much apart from that I didn’t notice much negative effects (apart from the short term burning due to DMSO). I want to use such a topical once every couple weeks or so.
I noticed quite a bit of improvement to the skin on my mid face. It appeared clearer and lifted. I noticed it a little after my 1st dose of D and Q but about 3 days after my 2nd dose my wife cornered me and asked me what I did to my face. She didn’t know I had experimented with the senolytics. She thought I had injected dermal fillers. I took 2.5 mg/kg of dasatinib and 20 mg/kg of Quercetin. I took 2 doses one week apart at these levels.