Sirolimus on Costplusdrugs

New to rapa community here. Just started taking sirolimus, ordered through CostPlusDrugs (shipped from HealthDyne pharmacy in FL). Titrating weekly up to target of 6 mg weekly. Will post in this thread my blood level ~90 minutes after taking while fasted in morning. Will also post 6 day (trough?) level. Please post your blood Sirolimus results from CostPlus if you are doing the same.

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The manufacturer for CostPlusDrugs sirolimus is Ascend Laboratories, and their website lists the inactive ingredients as “EDETATE DISODIUM, POLOXAMER 188, HYPROMELLOSE 2910 (5 MPA.S), SUCROSE , ALPHA.-TOCOPHEROL, DL, MICROCRYSTALLINE CELLULOSE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, GLYCERYL DIBEHENATE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, TITANIUM DIOXIDE, GLYCERYL MONOCAPRYLOCAPRATE, SODIUM LAURYL SULFATE, TALC.”

Any biochemist in this community know if these ingredients point to enteric coating or another mechanism of bypassing the stomach?

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If it’s a tablet it must be enteric coated, else it’s pretty much a fake product as it doesn’t increase sirolimus levels. It is unlikely they will have such a product for organ transplants etc.

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How do you test your blood for rapamycin that fast?

I’ve ordered 2 lab requisitions for Labcorp through Life Extension. Will schedule blood draws to time them for peak and then trough blood levels.

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