@mkaeberlein love this:
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Sinclair is looking more and more sketchy by the moment. Will be interesting to see if he actually tries to rebut this (so far heās just dodging, as Stanfieldās short new video from today shows:
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Apart from the sketchiness reg. overhyping resveratrol, NAD, etc. I also find his personal anti-aging regimens very weird, and different from what I would personally follow.
Nothing based on ITP results for example: The Anti-Aging Supplements David Sinclair Takes | Skeptical Review
Itād be perfectly fine to be transparent about the failure of SIRT related experiments (designing good experiments is hard) and still talk about why it may still be worth pursuing based on any theoretical merits. But he never does that.
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Charles brenner has a good thread about why/how david is wrong. He has been debunking a lot of what David has been saying for a long time now
Just scroll through his twitter page and you will see a good amount of threads about david being wrong with his claims .
Here is the link to his most recent one:
I like Brennerās contrarian view on anti aging, although I think he is completely wrong about rapamycin and some other things. I find him a good source and have talked to him too. He is a good scientist
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A critique of David Sinclairās book on aging. And, a reminder that all we can do at this stage is slow down aging. That is why as I have stated elsewhere that I am very much in favor of starting young. Donāt wait until you are sixty. Fortunately, I inadvertently did some of the things that help to slow aging such as stopping smoking and drinking at a young age and taking various supplements that health gurus were promoting, not for anti-aging, but for general health concerns.
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I donāt understand why he keeps pushing the sirtuin hypothesis so hard when his labs have also worked on other really impressive technologies. The epigenetic reprogramming in the eye was huge, now moving on to human trials. NAD boosters, while not having success in ITP still have a lot of good evidence that they can be helpful in at least ameliorating various age-related problems.
I also think that he is the main reason longevity finally went mainstream. He was out there talking about aging as a disease when nobody else was. Every longevity scientist who a has been invited onto podcasts, who has written books recently, who has had high net worth individuals looking to fund their researchā¦ they owe a lot of that to David Sinclair pounding the pavement and spreading the idea that aging was treatable to anyone who would listen. Would Altos Labs have had the billionaire funders ready to pour infinite money into the project without him laying the educational groundwork for years before that?
Still, he needs to let the sirtuins go for now unless heās going to do new research that will change the body of evidence. It doesnāt do him any good to cling to something that has murky results at best.
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He is good at PR and he looks good himself. Aubrey de Grey is good at PR. To what extent their science is good is another issue.
My view on OSKM is that it kicks off solid autophagy. Where the cell ends up is another issue.
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