Siim Land: Biohacking Longevity, Health Span Truths & Cutting Through th

#1

New Kaeberlein optispan with health span influencer Siim Land.

If you are a Kaeberlein groupie like me… I can’t get enough of his full honesty and critical review of unsubstantiated claims and misinformation.

Matt K. and P. Attia podcasts deep dives on aging and rapamycin got me started on rapamycin.

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#2

I recommend this podcast. I was just going to post this episode, In the start of the show he makes some very good points about not taking medical advice from Bryan Johnson. What do people think about this talk? Did I hear Growth Hormone, DHEA and Metformin? Interesting

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#4

Reached 21:49. Nothing substantial yet. Clicking out now.

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#5

I don’t think it’s accurate to put undue weight that Bryan quit rapamycin because of the biological age paper. And it’s pretty simple to know if you get the common side effects from rapamycin. Your side effects improve after you quit it.

Sure we can’t know whether it was nocebo or placebo or something else because of N=1, but it’s not like most of these side effects haven’t been reported elsewhere and in the literature. I think it would be interesting to see if side effects are lower for those who get them at lower doses or different formulations.

Polypharmacy if they don’t affect e.g CYP3A4 might be additive, not suddently reverse to be negative, if we see what polygenic genomics can teach us, Kamil Pabis has written about this on his blog.

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#6

So thankful Kaeberlein has Bryan Johnson to complain about now, not just the Harvard guy. Variety is the spice of life, Maslow 101.

Someone please develop an AI that can listen to a video, and generate an accurate transcipt - and not get the speakers mixed up.

Or maybe make a GLP-1, but for video consumption.

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#7

I’m so sorry, and apologize profusely ahead of time, but can someone do a bullet point list of value added health insights from the over an hour long interview blob?

While I value MK’s health related contributions, his own podcast I find severely undewhelming 90% of the time. It’s either pitched at the lowest common denominator viewer with 101 level standard nostrums, or the guests are pointless zero value influencers plus some dodgy kooks.

I actually listened to the full interviews of health knowledge non-entities with outsize subscription numbers, the deLaurers, Muntzls and other assorted yt cash grabbers, and found zero value. I can only speculate as to why he does it - perhaps he’s hoping to leach away some subscribers from these more popular guys… if so, it’s doomed to fail. A deLaurer subscriber is only going to be interested in 101 stuff - is this what MK is hoping to attract, giving up his own comparartive advantage and differentiating high level content? Regardless, this will backfire. It’ll discourage more serious listeners, and not result in success in competition with far more slick clickbait optimizers and supplement pill pushers like Mutzel. And yet, it’s possible to have modest success with deep dives into science - look at Simon Hill and his The Proof podcast - he has a fraction of MK’s qualifications, does a metric ton of deep dives and has a modest but growing sub count. MK, IMHO should rethink the orientation of his podcast, BWDIK.

As a result I’m reluctant to waste another hour+ on this Land guy. I’m aware of who he is, some years ago I watched one of his videos and it was clear to me that he’s just another no value added grifter infesting this space, hoping to rob you of your time to monetize clicks.

Frankly, I much prefer MK on other peoples podcasts to his own performance on his own podcast. Very sad, that I’m forced to have so little faith in his efforts in this area that I must rely on the kindness of others in giving me a heads up. TIA!

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#8

Yeah tbh not an attention grabbing guest. Siim comes off too young and not willing to be out there with a strong opinion. Caspar Milquetoast.

I am probably too old… 67 years on Saturday. Ugh.

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#9

Hey there, at least you made it in good shape… I myself am hitting 67 next month, also in reasonable shape - if I say so myself - judging by friends and acquaintances in the same age group. Glass half full.

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#10

congratulations. Have a nice day.

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#11

I agree with you that Siim is too young, I’m happy to see the younger folks taking an interest in longevity, but a young person might respond very different than someone much older than him. A strong opinion would be helpful.

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#12

I also found too long and too superficial, learned nothing new.

I was wondering how to avoid wasting my time in the future
I tried copiing the youtube transcript in a txt file and asking ChatGPT to give me a summary. Works pretty well.

I also asked what the 3 main insigths were:

  1. Focus on healthspan over lifespan
  • The hosts argue that living longer is meaningless without good quality of life.
  • They encourage listeners to prioritize avoiding chronic disease, preserving metabolic flexibility, and maintaining strength and cognition into old age.
  • “Don’t chase immortality — chase functionality.”
  1. Basic lifestyle choices still outperform fancy interventions
  • The best interventions remain boring and obvious: exercise, sleep, whole food nutrition, and stress management.
  • Advanced supplements, extreme biohacks, or expensive protocols like Bryan Johnson’s “Blueprint” may have marginal gains, but the fundamentals matter more.
  • There’s skepticism around overreliance on tracking or quantified-self gadgets if people haven’t mastered basic habits.
  1. The science doesn’t support radical life extension yet
  • They criticize longevity escape velocity and the hype surrounding it.
  • No intervention has yet shown convincing evidence of lifespan extension in humans, especially not in healthy individuals.
  • They urge a measured, skeptical approach: track biomarkers, yes, but don’t get swept up in the Silicon Valley optimism.

I then asked for both parties position on Rapamycin
Matt Kaeberlein (host)

  • Critical of rapamycin skeptics, specifically naming Bryan Johnson as spreading misinformation.
  • Suggests that the data on rapamycin is often misrepresented, and he’s concerned about influential figures dismissing it without proper nuance.
  • Implies that while rapamycin is not a miracle drug, the scientific evidence behind it is stronger than what some critics claim​.

Siim Land (guest)

  • Doesn’t directly take a strong stance on rapamycin in the transcript, but agrees in general with Matt’s concern about overstated claims in the longevity world.
  • Emphasizes lifestyle over pharmacological interventions, implying that drugs like rapamycin might be overhyped if not guided by data and context.

Summary:

  • Kaeberlein defends rapamycin against unfair criticism and stresses its evidence base.
  • Siim Land seems cautious and reserved, aligning more with prioritizing lifestyle and careful interpretation of data.
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#13

Thank you guys, you saved me an hour of low value waffling.

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#14

Here’s a more succinct approach–and not one word about he who must not be named.

“It’s estimated that at least 80 percent of cardiovascular disease cases, 40 percent of cancer cases and 45 percent of Alzheimer’s cases are preventable.”

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