Side Effects of Rapamycin (part 2)

@adriank

Did that enlarged tonsil effect go away after a while? I am getting the same thing where I can feel them enlarged (especially when eating) but there is no sore throat or illness like other times which is weird.

not really for me. I don’t notice them as much.

Garden insect bites…6 months ago, I restarted Rapamycin 7 mg with naringin an hour ahead of time one day a week, . I paused to allow my knee replacement to heal. But now is my garden time (my Mini Iowa farm), and I noticed that the mosquitos, gnats, or maybe biting flies seemed more awful than I had ever experienced before, with large itchy welts that last for multiple days. I have even purchased a bug net suit. So I wonder if this has been seen with Rapamycin. Im definitely considering skipping a week. Also first cold sore since my 20s. Has anyone had this experience?

Yes, I get those nasty welts as well. I originally thought they were from mosquitoes or gnats, but it turns out they’re from the Rapamycin. I posted pictures earlier in this thread.

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I did get bit by mosquitos and gnats, but my reaction is over the top. I am definitely skipping at least one dose. Previously thought I was ā€œimmuneā€ from the side effects…

I’m on my 2nd dose of Rapamycin at 3mg, I’ve got a pretty bad mouth sore. I’m skipping this coming dose and will resume next week.

I’m going to be getting some remedies for mouth sores on hand for any situation like this in the future. It would be handy to be able to eliminate them quickly and not have to skip a dose.

Peter Attia uses something called Debacterol but it doesn’t seem easy to get right now. There is an alternative similar product named UlcerMagic which isn’t exactly the same but is similar.

Salt water gargling doesn’t seem to solve the issue. Xylitol doesn’t solve it. Listerine mouthwash stops it hurting for a bit but doesn’t solve it.

I’m also considering lysine powder. This activates mTOR, but it might be good to have on hand in cases of this. Or it might be good to dose a few days after dosing rapamycin as a preventative.

Elsewhere someone mentioned a product named ā€œwatermelon frost powderā€.

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I will get a canker sore if I dose >10mg. I normally take 9mg with no sides.

If it’s herpes, Lysine is an excellent choice, and if you keep it to .5g on an empty stomach in mult doses, unlikely to upregulate mTOR. Give it a go.

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I’ll try it, it’s pretty cheap. I don’t think I have herpes but who knows. Doesn’t it also manifest in other ways though like coldsores? I never get coldsores.

I don’t know much about mouth sores other than those caused by herpes. Which rapa does cause in some people. You could still try lysine, of course, but I can’t answer your question, alas.

no grapefruit juice? I do 4mg with GFJ… but it is so bothersome.

Lysine is cheap. I’ve ordered some and I will report back if it helps. If not I’ll have to try the topical product UlcerMagic that I mentioned earlier.

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Yes GFJ 10oz. one hour before taking 3mg. Sometimes I just eat a GF instead.

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I am contemplating taking 5mg with GFJ on a 10 day cycle… so 2x a month … on the first and on the 10th and then wait until the next 1st again… so 20 days with rapamycin and 10 days to clear it out. This will allow me to manage my fasting better … to 4 days after rapamycin x2 a month. Once I reduce to my desired weight I will drop the fasting to 3 days and then 2 days and maybe 1 day. With GFJ best to take rapamycin after 2 hours to maximize the strength.

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