I can definitely feel it as well, but I do take a lot of supplements so it’s hard to tell what comes from what. My grey hair has turned brown again (mostly) and I have lost adipose tissue around my waist. However, my overall weight has not decreased. I don’t work out heavily (other than walking) so I am not sure where the weight went?!
For Rapamycin, I have found the following effects:
Euphoria/Nausea for the two days after oral ingestion of 2 mg +GFJ + Metformin
Neck acne and rashes (1 of each)
Back of hand rash (1)
Canker sores (1 per week)
I hope there are some good changes going on inside me as well, but those are much harder to quantify than the negative side effects! I will be getting my next blood work done in January to see any effects on cholesterol or blood glucose. I am a bit younger at 47.
Seems like I will be delayed from taking Rapamycin for another 3 weeks. I have developed an infected cyst on my right shoulder and will need it to be surgically removed. This has happened to me in the past and usually not a big deal. However it can easily get reinfected and the wound needs to heal quickly. So, no Rapa for another month.
I usually get one of these suckers every 2 years, although it has been 17 months since the last one. Since it is a bacteria that lives in your body, I wonder if Rapamycin sped up the infection process due to a weaker immune system? If so, that would not be good.
The first and second times, I was only taking Metformin. Now I take a much larger stack of vitamins and supplements. Honestly, 5 months isn’t a whole lot earlier, but still earlier. Prior to 40, I never had any issues with this.
That looks like very mild rash, my acne is 4 times larger than you lol, so no worry about that.
My personal experience: Acne on face are usually bigger and more painful than rash on torso.
I guess maybe the oil produced by sebaceous glands exacerbates the acne on face.
Now I am more concerned. The infection I have is a sebaceous cyst which originates from the sebaceous gland. If the acne and rashes are tied to the same source, then it is quite possible that this cyst infection could also be tied to Rapamycin use.
I am going to try antibiotics first before surgery to see if I can get it tamed. However, I feel like antibiotics are probably not good for my microbiome.
Sorry to hear that, DeStrider. Sorry if you mentioned, but could I ask what dose you have been taking? (Was it 6mg per week, generic Rapa, did you ever measure your Sirolimus serum levels?) I share your concern about taking antibiotics, and prefer not to take antibiotics if not necessary. On the other hand, albeit different from other broad-spectrum antibiotics, Sirolimus is a macrolide antibiotic in itself. And you’d rather be safe than sorry. So in this situation I would personally certainly try the antibiotics.
Infection has been a concern of me as well. Admittedly, with the side-effects I have thus far experienced, I can’t help but feel I’m walking a thin line and wonder at moments if and when a real adverse event may kick in. Either way, I really hope the antibiotics will help for you. Staying away from Rapa for some time sounds like a smart move.
I was taking 2 mg Rapamycin + GFJ + EVOO + Metformin weekly in addition to an indeterminate amount dissolved in DMSO applied to the scalp daily. It appears that there was enough Sirolimus in the DMSO to continue side-effects even after I stopped taking Rapamycin orally.
The cyst infection appears to be getting better, but I am unsure if it will be cleared up after one treatment of antibiotics.
The surgery sounds much worse than it is. The doctor makes a small incision, drains the infected cyst and removes it. Then I need to get it cleaned daily at the clinic to prevent further infection and wait for it to heal. It is usually a fairly deep hole (about as deep as the length of a man’s fingernail) that needs to close up and it usually takes a couple of weeks.
I knocked up a mixture of 60% thymol, 20% eucalyptus, 20% peppermint and some bits of other essential oils. You might add in carvacrol or little bits of clove.
However, this should then be diluted with water (20% mix 80% water). Carvacrol is oregano oil.
That mix I used to manage dental infection.
If you are going for a simple solution perhaps just dissolve thymol. There are papers that look at the effectiveness of essential oils vs antibiotics. If you want me to hunt them up ask and I will, but not necessarily immediately.
This is for topical use. Given what I have learnt more recently I might add in some DMSO to see if that gets it through the skin. However, I have not done any testing of that and I would be careful.
On a quick search I have found this:
That is using cinnamon oil which is another of the oils which has antimicrobial activity.
I would start looking at 20% essential oils, 20% DMSO and 60% water. However, I have no experience with using DMSO this way and you need to do your own research on that.
Please explain this: My understanding is if you take 6mg without GFJ, your body only absorb about 2 mg due to low bioavailability. if you are taking 6mg with GFJ, the maximum dosage from the pills cannot exceed 6mg of the pills, because where do you get the extra 24 mg of sirolimus out of 6mg pills?
The most effective from the point of view of concentration was Clove Oil, then Peppermint,Then Tea Tree, Then Thyme then Lavender. Thymol and Tea Tree were about the same. (22/17)
Antibiotics are working really well so far. Inflammation and pain are almost gone, although the cyst and associated bump are still there. I may need the surgery to remove that. Such an annoying pain in the neck.
Just FYI, I do not think this is Rapamycin related. I have just continued to stop dosing until it is all resolved. I need a heightened immune system and wound healing right now.
I use silver gel, a fairly inexpensive gel, from silver biotics, as the first line of defense against minor skin infections. it is also anti-viral and will knock out a herpes simplex sore immediately. I also use liquid colloidal silver for mouth sores. Swish it around and swallow or spit. None of my mouth sores have lasted longer than 12 hours. Another great anti-bacterial for cyst like lesions is 10% benzoyl peroxide.
I visited pharmacies over here the past weeks, and it turned out Lmitrex in several European countries is only available per prescription. My GP agreed today to prescribe it, so I can finally give it a try once needed. Thanks for the recommendation.
Unfortunately my GP didn’t feel comfortable to prescribe Provigil for the fatigue. He didn’t feel comfortable with its potential side-effects/safety profile he said. (But on the other hand he also readily admitted that he didn’t really know what Provigil is normally prescribed for, and was using Google to find more info . I was too uninformed myself also).
. I was too uninformed myself also).